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介导的银纳米粒子的抗菌、清除自由基和抗癌潜力的特性研究。

The Characterization and Study of Antibacterial, Free Radical Scavenging, and Anticancer Potential of -Mediated Silver Nanoparticles.

机构信息

Institute of Industrial Biotechnology (IIB), Government College University Lahore, Lahore 54000, Pakistan.

Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

出版信息

Molecules. 2023 Nov 25;28(23):7773. doi: 10.3390/molecules28237773.

DOI:10.3390/molecules28237773
PMID:38067504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10708060/
Abstract

In the present research, leaf extracts were utilized as reductants to bio-fabricate silver nanoparticles (LC-AgNPs) and this was followed by the evaluation of their antioxidant, antibacterial, and anticancer potential. Multiple parameters were optimized for the formation and fidelity of LC-AgNPs. The color shift of the reaction mixture from yellow to dark brown confirmed the LC-AgNPs formation. UV/VIS spectroscopy exhibited a surface plasmon resonance (SPR) band at 436 nm. The Fourier transform infrared (FTIR) spectroscopy spectrum depicted phytochemicals in the plant extract acting as bio-reducers for LC-AgNPs synthesis. The XRD pattern confirmed the presence of LC-AgNPs by showing peaks corresponding to 2θ angle at 8.24° (111), 38.16° (200), 44.20° (220), and 64.72° (311). Zetasizer analysis exhibited size distribution by intensity of LC-AgNPs with a mean value of 255.7 d. nm. Moreover, the zeta potential indicated that the AgNPs synthesized were stable. The irregular shape of LC-AgNPs with a mean average of 38.46 ± 0.26 nm was found by scanning electron microscopy. Furthermore, the antioxidant potential of LC-AgNPs was examined using a DPPH assay and was calculated to be higher in LC-AgNPs than in leaf extracts. The calculated IC values of the LC-AgNPs and plant extract are 85.01 ± 0.17 and 209.44 ± 0.24, respectively. The antibacterial activity of LC-AgNPs was investigated against , , and as well as and maximum potential was observed after 24 h against . Moreover, LC-AgNPs exhibited maximum anticancer potential against TPC1 cell lines compared to the plant extract. The findings suggested that LC-AgNPs could be used as antioxidant, antibacterial, and anticancer agents for the cure of free-radical-oriented bacterial and oncogenic diseases.

摘要

在本研究中，利用叶提取物作为还原剂来生物制造银纳米粒子（LC-AgNPs），并评估其抗氧化、抗菌和抗癌潜力。优化了多个参数以形成和保真度 LC-AgNPs。反应混合物从黄色变为深棕色的颜色变化证实了 LC-AgNPs 的形成。紫外/可见光谱在 436nm 处显示出表面等离子体共振（SPR）带。傅里叶变换红外（FTIR）光谱图显示植物提取物中的植物化学物质作为生物还原剂合成 LC-AgNPs。X 射线衍射（XRD）图谱通过显示对应于 2θ 角为 8.24°（111）、38.16°（200）、44.20°（220）和 64.72°（311）的峰来证实 LC-AgNPs 的存在。Zetasizer 分析通过 LC-AgNPs 的强度显示粒径分布，平均值为 255.7d。nm。此外，zeta 电位表明合成的 AgNPs 是稳定的。通过扫描电子显微镜发现 LC-AgNPs 的形状不规则，平均粒径为 38.46±0.26nm。此外，通过 DPPH 测定法检查了 LC-AgNPs 的抗氧化潜力，并发现 LC-AgNPs 的抗氧化潜力高于叶提取物。LC-AgNPs 和植物提取物的计算 IC 值分别为 85.01±0.17 和 209.44±0.24。研究了 LC-AgNPs 的抗菌活性，结果表明，LC-AgNPs 对 、 、 和 以及 具有抗菌活性，24 小时后对 表现出最大潜力。此外，与植物提取物相比，LC-AgNPs 对 TPC1 细胞系表现出最大的抗癌潜力。研究结果表明，LC-AgNPs 可用作抗氧化、抗菌和抗癌剂，用于治疗自由基导向的细菌和致癌性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/73cb9aa1ccb5/molecules-28-07773-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/ba39fdd68a80/molecules-28-07773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/17f4367359f2/molecules-28-07773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/01fe2a58cb9f/molecules-28-07773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/1c6150167b8b/molecules-28-07773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d376e0a95cf5/molecules-28-07773-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/ffe758f734fa/molecules-28-07773-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d57c6445e66c/molecules-28-07773-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/70e3d5ef8948/molecules-28-07773-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d15a3d5edca7/molecules-28-07773-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/1696e77b8bb8/molecules-28-07773-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/be385b6a7ca8/molecules-28-07773-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/73cb9aa1ccb5/molecules-28-07773-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/ba39fdd68a80/molecules-28-07773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/17f4367359f2/molecules-28-07773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/01fe2a58cb9f/molecules-28-07773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/1c6150167b8b/molecules-28-07773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d376e0a95cf5/molecules-28-07773-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/ffe758f734fa/molecules-28-07773-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d57c6445e66c/molecules-28-07773-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/70e3d5ef8948/molecules-28-07773-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/d15a3d5edca7/molecules-28-07773-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/1696e77b8bb8/molecules-28-07773-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/be385b6a7ca8/molecules-28-07773-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d4/10708060/73cb9aa1ccb5/molecules-28-07773-g012.jpg

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