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澳大利亚一家三级医院围产期子宫切除术发生率的回顾。

Review of peripartum hysterectomy rates at a tertiary Australian hospital.

作者信息

Cheng Hon C, Pelecanos Anita, Sekar Renuka

机构信息

Department of Obstetrics & Gynaecology, Royal Brisbane and Women's Hospital, Queensland, Australia.

QIMR Berghofer Medical Research Institute, Queensland, Australia.

出版信息

Aust N Z J Obstet Gynaecol. 2016 Dec;56(6):614-618. doi: 10.1111/ajo.12519. Epub 2016 Aug 17.

Abstract

BACKGROUND

Peripartum hysterectomy is commonly performed for catastrophic postpartum haemorrhage uncontrolled by conservative medical and surgical therapies. Currently, information about the incidence and indications for peripartum hysterectomy are not well defined in Australia.

AIMS

Evaluate the incidence and indications of peripartum hysterectomy in the Royal Brisbane and Women's Hospital (RBWH) between 2000 and 2014.

MATERIALS AND METHODS

A 15-year retrospective cohort study of peripartum hysterectomies at RBWH was conducted. The incidence of this event was calculated. Risk factors for abnormal placentation were explored using univariate analyses. Statistical significance was declared at α < 0.05.

RESULTS

A total of 83 cases of peripartum hysterectomy were reviewed. The incidence of peripartum hysterectomy was 0.60 per 1000 births after discounting the 44 (53%) cases of peripheral regional hospital referrals. Abnormal placentation and uterine atony constituted the majority of the indications for peripartum hysterectomy. Abnormal placentation included placenta praevia, accrete, increta and percreta. In this cohort with peripartum hysterectomy, previous caesarean section was strongly associated with abnormal placentation (P < 0.001, OR 11.4, 95% CI 3.6-35.8). No maternal mortality was recorded, although 63% of patients encountered complications. A planned peripartum hysterectomy resulted in significantly fewer red blood cell (P = 0.011) and platelet transfusions (P = 0.001).

CONCLUSIONS

The incidence of peripartum hysterectomy recorded in our tertiary institution between 2000 and 2014 is 0.60 per 1000 births. Abnormal placentation is the commonest indication leading to severe postpartum haemorrhage requiring peripartum hysterectomy.

摘要

背景

围产期子宫切除术通常用于治疗经保守药物和手术治疗无法控制的灾难性产后出血。目前,澳大利亚围产期子宫切除术的发病率和适应症信息尚不明确。

目的

评估2000年至2014年期间皇家布里斯班妇女医院(RBWH)围产期子宫切除术的发病率和适应症。

材料与方法

对RBWH的围产期子宫切除术进行了一项为期15年的回顾性队列研究。计算该事件的发病率。使用单因素分析探讨胎盘异常植入的危险因素。当α<0.05时具有统计学意义。

结果

共回顾了83例围产期子宫切除术病例。排除44例(53%)外周地区医院转诊病例后,围产期子宫切除术的发病率为每1000例分娩0.60例。胎盘异常植入和子宫收缩乏力是围产期子宫切除术的主要适应症。胎盘异常植入包括前置胎盘、粘连性胎盘、植入性胎盘和穿透性胎盘。在这个围产期子宫切除术队列中,既往剖宫产与胎盘异常植入密切相关(P<0.001,OR 11.4,95%CI 3.6-35.8)。尽管63%的患者出现了并发症,但未记录到孕产妇死亡病例。计划性围产期子宫切除术导致红细胞(P=0.011)和血小板输注(P=0.001)显著减少。

结论

2000年至2014年期间,我们三级医疗机构记录的围产期子宫切除术发病率为每1000例分娩0.60例。胎盘异常植入是导致严重产后出血需要进行围产期子宫切除术的最常见适应症。

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