Meylaerts Liesbeth J, Wijnen Leen, Ombelet Willem, Bazot Marc, Vandersteen Marjan
Department of Medical Imaging, Ziekenhuis Oost-Limburg, Genk, Belgium.
Faculty of Medicine and Biomedicine, Hasselt University, Diepenbeek, Belgium.
J Magn Reson Imaging. 2017 Mar;45(3):926-936. doi: 10.1002/jmri.25422. Epub 2016 Aug 18.
To prospectively evaluate and compare the junctional zone (JZ) and outer myometrial thickness in infertile and healthy nulliparous women at different locations in the uterine wall during the menstrual cycle by magnetic resonance imaging (MRI).
We performed pelvic 1.5T MRI (T -weighted turbo spin echo sequences) on 28 infertile women: 5 with infertility of unknown origin, 12 anovulating, and 11 on ovarian stimulation therapy (mean age 28.5, 30.8, and 29.3 years, respectively); and a control group consisting of 18 healthy nulliparous volunteers (mean age 26.4 years). The women with unknown infertility origin and the control group underwent MRI investigations during their follicular, ovulatory, and luteal phase. The JZ and outer myometrial thicknesses were measured at six locations in the uterine wall: anterior and posterior wall of the isthmus, midcorpus, and fundus.
The JZ in the anovulating women at the posterior wall of the isthmus (4.2 mm) was significantly thicker compared to the control group (3.2, 3.0, and 2.9 mm, in respectively the three menstrual phases) (P = 0.027). The outer myometrium in the anovulating women was significantly thicker at all measured locations (average 11.5 mm) in comparison to the control group (8.1, 8.0, and 8.5 mm, in respectively the three menstrual phases) (P < 0.050). The infertile women on ovarian stimulation therapy showed a significantly thicker outer myometrium at the anterior wall (isthmus, midcorpus, and fundus) (P < 0.050).
The results indicate that a thickened JZ, and especially a thickened outer myometrium, might be associated with infertility.
1 J. Magn. Reson. Imaging 2017;45:926-936.
通过磁共振成像（MRI）前瞻性评估并比较月经周期中不同子宫壁位置的不孕未育女性和健康未育女性的结合带（JZ）及子宫肌层外层厚度。
我们对28名不孕女性进行了盆腔1.5T MRI检查（T加权快速自旋回波序列）：5名不明原因不孕者、12名无排卵者以及11名接受卵巢刺激治疗者（平均年龄分别为28.5岁、30.8岁和29.3岁）；并设立了一个由18名健康未育志愿者组成的对照组（平均年龄26.4岁）。不明原因不孕的女性和对照组在卵泡期、排卵期和黄体期接受MRI检查。在子宫壁的六个位置测量JZ和子宫肌层外层厚度：峡部前壁和后壁、子宫体中部以及宫底。
无排卵女性峡部后壁的JZ（4.2毫米）明显厚于对照组（三个月经周期分别为3.2毫米、3.0毫米和2.9毫米）（P = 0.027）。无排卵女性在所有测量位置的子宫肌层外层均明显更厚（平均11.5毫米），相比之下对照组在三个月经周期分别为8.1毫米、8.0毫米和8.5毫米（P < 0.050）。接受卵巢刺激治疗的不孕女性在前壁（峡部、子宫体中部和宫底）的子宫肌层外层明显更厚（P < 0.050）。
结果表明JZ增厚，尤其是子宫肌层外层增厚，可能与不孕有关。
1 J. Magn. Reson. Imaging 2017;45:926 - 936。
