Franklyne J S, Mukherjee A, Chandrasekaran N
Centre for Nanobiotechnology, VIT University, Vellore, Tamil Nadu, India.
Lett Appl Microbiol. 2016 Nov;63(5):322-334. doi: 10.1111/lam.12631. Epub 2016 Oct 1.
Antimicrobial resistance is a major health concern worldwide. A narrowing of the antibiotic development pipeline and a resurgence in public opinion towards 'natural' therapies have renewed the interest in using essential oils as antimicrobial agents. The drawbacks of bulk dosing of essential oils can be mitigated by formulating them as micro- and nanoemulsions. These emulsions have an added advantage as they are in the nanometre size range whose thermodynamic properties enable them to be used as an effective drug delivery system. This review describes the current work on the antimicrobial activities of essential oil micro- and nanoemulsions and their role as drug delivery vehicles.
抗菌耐药性是全球主要的健康问题。抗生素研发渠道的变窄以及公众舆论对“天然”疗法的再度关注,重新引发了人们对使用精油作为抗菌剂的兴趣。将精油制成微乳液和纳米乳液可以减轻大量使用精油的弊端。这些乳液具有额外的优势,因为它们处于纳米尺寸范围,其热力学性质使其能够用作有效的药物递送系统。这篇综述描述了目前关于精油微乳液和纳米乳液抗菌活性及其作为药物递送载体作用的研究工作。