Bleisch W V, Harrelson A
Rockefeller University, New York, New York 10021.
J Neurobiol. 1989 Jun;20(4):189-202. doi: 10.1002/neu.480200403.
The dorsal bulbocavernosus or "levator ani" muscle of the rat is highly responsive to androgens. Both the muscle and the motoneurons which innervate it contain high concentrations of androgen receptors. The neuromuscular synapses in this muscle are also affected by changing androgen levels. In particular, the total number of ACh receptors (AChRs) in the muscle is lower in males that have been castrated, and it increases after treatment with the androgens, testosterone and 5 alpha-dihydrotestosterone. An examination of individual endplates using histochemistry and quantitative autoradiography suggested that the reduction in AChR number following castration is caused by reductions in both the size of endplates and in the density of AChRs at each synapse.
大鼠的球海绵体背侧肌或“提肛肌”对雄激素高度敏感。该肌肉及其支配的运动神经元都含有高浓度的雄激素受体。此肌肉中的神经肌肉突触也会受到雄激素水平变化的影响。特别是，阉割后的雄性大鼠肌肉中乙酰胆碱受体（AChRs）的总数会减少，而在用雄激素、睾酮和5α-二氢睾酮治疗后会增加。使用组织化学和定量放射自显影对单个终板进行检查表明，阉割后AChR数量的减少是由终板大小和每个突触处AChRs密度的降低共同导致的。
