Wagner I V, Klöting N, Atanassova N, Savchuk I, Spröte C, Kiess W, Söder O, Svechnikov K
Karolinska Institutet, Department of Women and Child Health, Pediatric Endocrinology Unit, 17171 Stockholm, Sweden; Center for Pediatric Research Leipzig, University Hospital for Children & Adolescents, Department of Women's and Child Health, University of Leipzig, Leipzig, Germany; Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
Mol Cell Endocrinol. 2016 Dec 5;437:154-162. doi: 10.1016/j.mce.2016.08.027. Epub 2016 Aug 17.
Obesity is a global health problem and impacts negatively on levels of testosterone and quality of sperm production. At present little is known about mechanisms that attenuate testicular function in obese males. Our study characterized testicular steroidogenesis and explored levels of relevant paracrine and hormonal factors in rats with short- and long-term obesity. We have found that obesity state increased serum levels of estradiol and leptin in both groups of obese rats and inhibited the expression of StAR and Cyp11a1 associated with low levels of intratesticular testosterone in rats with long-term obesity. Further, long-term obesity reduced the number of Leydig cells, increased the testicular levels of the proinflammatory adipocytokine TNFα and the number of testicular macrophages. All together, our data indicate that long-term obesity may cause chronic inflammation in the testis and negatively impacts on Leydig cell steroidogenesis.
肥胖是一个全球性的健康问题，对睾酮水平和精子生成质量有负面影响。目前，对于肥胖男性睾丸功能减弱的机制知之甚少。我们的研究对短期和长期肥胖大鼠的睾丸类固醇生成进行了表征，并探索了相关旁分泌和激素因子的水平。我们发现，肥胖状态增加了两组肥胖大鼠的血清雌二醇和瘦素水平，并抑制了长期肥胖大鼠中与睾丸内睾酮水平低相关的StAR和Cyp11a1的表达。此外，长期肥胖减少了睾丸间质细胞的数量，增加了促炎脂肪细胞因子TNFα的睾丸水平和睾丸巨噬细胞的数量。总之，我们的数据表明，长期肥胖可能导致睾丸慢性炎症，并对睾丸间质细胞类固醇生成产生负面影响。
