Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, México D.F., México.
Acta Histochem. 2011 Feb;113(2):214-20. doi: 10.1016/j.acthis.2009.10.004. Epub 2010 Feb 9.
In order to assess the effect of obesity on epididymal and germinal epithelia in control rats and obese rats induced by a high fat diet, we evaluated the epididymal and testicular morphologies, lipid peroxidation in the epididymis, leptin serum levels, steroid hormones, insulin, cholesterol, triglycerides, glycemia and some spermatobioscopic parameters. No significant difference was observed in the levels of insulin, glucose, cholesterol and triglycerides between the two groups. Nonetheless, in the obese rats, circulating leptin and estradiol levels showed a significant increase and there was a decline in the testosterone levels. The same group showed an increase in the lipid peroxidation of the epididymis and reduced spermatobioscopic parameters. The heads of the epididymis showed morphological differences in obese rats. No significant difference was observed between the testes of both groups. There is a clear evidence of an effect on sperm in obese rats and this seems to occur in the epididymis.
为了评估肥胖对对照大鼠和高脂肪饮食诱导肥胖大鼠附睾和生殖上皮的影响，我们评估了附睾和睾丸的形态、附睾的脂质过氧化、血清瘦素水平、甾体激素、胰岛素、胆固醇、甘油三酯、血糖和一些精子生物光学参数。两组间胰岛素、血糖、胆固醇和甘油三酯水平无显著差异。然而，肥胖大鼠的循环瘦素和雌二醇水平显著升高，而睾酮水平下降。同一组大鼠的附睾脂质过氧化增加，精子生物光学参数减少。肥胖大鼠的附睾头部出现形态学差异，两组睾丸无明显差异。肥胖大鼠的精子明显受到影响，这种影响似乎发生在附睾。
