Ogawa T
Nihon Jibiinkoka Gakkai Kaiho. 1989 Mar;92(3):334-46. doi: 10.3950/jibiinkoka.92.334.
We report a clinicopathological study in 193 cases with squamous cell carcinoma (SCC) in the sino-nasal cavity. Squamous metaplasia were found in 62.6% and squamous dysplasia in 25.3% of the SCC cases. These lesions seem to be important factors related with cancer development. Etiologically, metaplasia was found to be related with age and sex (male-dominant), but not with smoking and history of sinusitis. Chronic inflammation, papillary or stratified proliferation and reserved cell hyperplasia were considered as factors inducing squamous metaplasia in review of pathological specimens. We infered from the distribution pattern of cytokeratin that it might occur serial changes from metaplasia, dysplasia, CIS to microinvasive carcinoma, whose phenomenon was commonly seen in cases of uterus squamous cell carcinoma.
我们报告了一项对193例鼻腔鼻窦鳞状细胞癌（SCC）的临床病理研究。在SCC病例中，62.6%发现有鳞状化生，25.3%发现有鳞状上皮发育异常。这些病变似乎是与癌症发生相关的重要因素。从病因学上看，化生与年龄和性别（男性占主导）有关，但与吸烟和鼻窦炎病史无关。回顾病理标本发现，慢性炎症、乳头样或分层状增生以及储备细胞增生被认为是诱导鳞状化生的因素。我们从细胞角蛋白的分布模式推断，其可能发生从化生、发育异常、原位癌到微浸润癌的系列变化，这种现象在子宫鳞状细胞癌病例中很常见。
