Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hyperlipidemia Research Center, Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Can J Diabetes. 2016 Dec;40(6):594-602. doi: 10.1016/j.jcjd.2016.05.016. Epub 2016 Aug 18.
Diabetes is a chronic disease, and its prevalence continues to rise and can increase the risk for the progression of microvascular (such as nephropathy, retinopathy and neuropathy) and also macrovascular complications. Diabetes is a condition in which the oxidative stress and inflammation rise. Heat shock proteins (HSPs) are a highly conserved family of proteins that are expressed by all cells exposed to environmental stress, and they have diverse functions. In patients with diabetes, the expression and levels of HSPs decrease, but these chaperones can aid in improving some complications of diabetes, such as oxidative stress and inflammation. (The suppression of some HSPs is associated with a generalized increase in tissue inflammation.) In this review, we summarize the current understanding of HSPs in diabetes as well as their complications, and we also highlight their potential role as therapeutic targets in diabetes.
糖尿病是一种慢性疾病，其患病率持续上升，会增加微血管（如肾病、视网膜病变和神经病变）和大血管并发症的风险。糖尿病是一种氧化应激和炎症增加的疾病。热休克蛋白（HSPs）是一组高度保守的蛋白质，所有暴露于环境应激的细胞都会表达，它们具有多种功能。在糖尿病患者中，HSPs 的表达和水平下降，但这些伴侣蛋白可以帮助改善糖尿病的一些并发症，如氧化应激和炎症。（一些 HSPs 的抑制与组织炎症的普遍增加有关。）在这篇综述中，我们总结了 HSPs 在糖尿病及其并发症中的最新认识，同时还强调了它们作为糖尿病治疗靶点的潜在作用。
