Kaźmierczuk Arleta, Kiliańska Zofia M
Zakład Biochemii Medycznej, Katedra Cytobiochemii, Uniwersytet Łódzki, Łódź.
Postepy Hig Med Dosw (Online). 2009 Oct 27;63:502-21.
Stress or heat-shock proteins (HSPs) are highly conserved proteins present in cells of both prokaryotes and eukaryotes, providing them with protection from cellular and environmental stress factors.Based on molecular-weight, HSPs can be divided into the large (HSP100: 100-110 kDa and HSP90: 75-96 kDa), intermediate (HSP70: 66-78 kDa, HSP60, and HSP40), and small (sHSP:8.5-40 kDa) subfamilies. These proteins play an essential role as molecular chaperones/co-chaperones by assisting the correct folding of nascent and stress-accumulated protein-substrate assembly,preventing the aggregation of these proteins, as well as transport across membranes and the degradation of other proteins. Members of HSP family display dual activity depending on the irintra- or extracellular distribution. Intracellular HSPs mainly play a protective role. Extracellular or membrane-bound HSPs mediate immunological functions. Among the functions of HSPs is their participation in cell signaling. This review deals with the structure and properties of the main members of the HSPs and their role in a large number of cellular/extracellular processes.
应激或热休克蛋白（HSPs）是原核生物和真核生物细胞中高度保守的蛋白质，可保护它们免受细胞和环境应激因素的影响。根据分子量，热休克蛋白可分为大分子量（HSP100：100 - 110 kDa和HSP90：75 - 96 kDa）、中等分子量（HSP70：66 - 78 kDa、HSP60和HSP40）和小分子量（小热休克蛋白：8.5 - 40 kDa）亚家族。这些蛋白质作为分子伴侣/共伴侣发挥着重要作用，协助新生蛋白和应激积累的蛋白 - 底物组装体正确折叠，防止这些蛋白质聚集，以及跨膜运输和其他蛋白质的降解。热休克蛋白家族成员根据其细胞内或细胞外分布表现出双重活性。细胞内热休克蛋白主要起保护作用。细胞外或膜结合的热休克蛋白介导免疫功能。热休克蛋白的功能之一是参与细胞信号传导。本文综述了热休克蛋白主要成员的结构和特性及其在大量细胞内/细胞外过程中的作用。
