胃肠道肿瘤的分子检测：早期检测与筛查的创新
Molecular Detection of Gastrointestinal Neoplasia: Innovations in Early Detection and Screening.
作者信息
Anderson Bradley W, Ahlquist David A
机构信息
Division of Gastroenterology & Hepatology, Mayo Clinic, Gonda Building E-9, 200 First Street SW, Rochester, MN 55905, USA.
Division of Gastroenterology & Hepatology, Mayo Clinic, Gonda Building E-9, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
Gastroenterol Clin North Am. 2016 Sep;45(3):529-42. doi: 10.1016/j.gtc.2016.04.009.
Emerging molecular tools promise to extend the diagnostic reach of the endoscopist and open doors to population screening for gastrointestinal (GI) cancers. This review briefly addresses biological considerations in marker detection and types of markers, highlights examples of tools under development at each organ site, and appraises the possibility of universal GI cancer screening. The outlook is positive, but further technical refinement and rigorous clinical validation are needed before most of these new approaches are ready for clinical application.
新兴的分子工具有望扩大内镜医师的诊断范围，并为胃肠道（GI）癌症的人群筛查打开大门。本文简要讨论了标志物检测中的生物学考量及标志物类型，重点介绍了各器官部位正在研发的工具实例，并评估了进行通用GI癌症筛查的可能性。前景是乐观的，但在这些新方法大多准备好临床应用之前，还需要进一步的技术改进和严格的临床验证。
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