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慢性淋巴细胞白血病患者亲属中单克隆B细胞淋巴细胞增多症的发生率。

Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia.

作者信息

Villegas Gracia Rossana, Franco Alzate Catalina, Rendón Henao Javier, Torres Hernández José Domingo, Jaramillo Arbelaez Patricia Elena

机构信息

Facultad de Ciencias de la Salud. Universidad de Córdoba. Monteria, Colombia.

Facultad de Medicina Universidad CES. Medellin, Colombia.

出版信息

Colomb Med (Cali). 2016 Jun 30;47(2):81-6.

Abstract

INTRODUCTION

Monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x10(9)/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined.

METHODS

Transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed.

RESULTS

Monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x10(9)/L and a B lymphocyte count of 0.124x10(9)/L; from these, 0.04x10(9)/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found.

CONCLUSION

Monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.

摘要

引言

单克隆B淋巴细胞增多症是一种无症状的病症,其特征是外周血中存在少量克隆性B淋巴细胞(少于5×10⁹/L)循环,这些细胞表达与慢性淋巴细胞白血病相似的免疫表型。基于大型医院系列的不同研究表明,单克隆B淋巴细胞增多症患者进展为慢性淋巴细胞白血病的风险更高。由于这种血液学实体的行为尚不清楚,因此确定了其在散发性慢性淋巴细胞白血病患者亲属中的发生率。

方法

进行横向描述性研究,使用欧洲流式细胞术推荐面板中的两根试管进行8色流式细胞术检测,并进行了修改,用于诊断B淋巴细胞慢性淋巴细胞增殖性疾病;此外,还进行了荧光原位杂交。对信息进行了单变量和双变量分析。

结果

在51名分析的亲属中发现单克隆B淋巴细胞增多症的发生率为2%,患者为一名59岁女性,白细胞总数为7.7×10⁹/L,B淋巴细胞计数为0.124×10⁹/L;其中,0.04×10⁹/L为具有κ轻链限制的克隆细胞。发现IGH基因(14q32)重排。

结论

在一名散发性慢性淋巴细胞白血病患者的亲属中检测到单克隆B淋巴细胞增多症,其发生率与普通人群中报道的发生率相似。

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