Satsangi Sandeep, Chawla Yogesh K
Senior Resident (Hepatology), Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Director, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Med J Armed Forces India. 2016 Jul;72(3):204-10. doi: 10.1016/j.mjafi.2016.06.011. Epub 2016 Aug 9.
Viral hepatitis is a cause for major health care burden in India and is now equated as a threat comparable to the "big three" communicable diseases - HIV/AIDS, malaria and tuberculosis. Hepatitis A virus and Hepatitis E virus are predominantly enterically transmitted pathogens and are responsible to cause both sporadic infections and epidemics of acute viral hepatitis. Hepatitis B virus and Hepatitis C virus are predominantly spread via parenteral route and are notorious to cause chronic hepatitis which can lead to grave complications including cirrhosis of liver and hepatocellular carcinoma. Around 400 million people all over the world suffer from chronic hepatitis and the Asia-Pacific region constitutes the epicentre of this epidemic. The present article would aim to cover the basic virologic aspects of these viruses and highlight the present scenario of viral hepatitis in India.
病毒性肝炎是印度主要的医疗负担原因,如今被视为与“三大”传染病——艾滋病毒/艾滋病、疟疾和结核病相当的威胁。甲型肝炎病毒和戊型肝炎病毒主要通过肠道传播,是导致散发性感染和急性病毒性肝炎流行的病原体。乙型肝炎病毒和丙型肝炎病毒主要通过非肠道途径传播,以导致慢性肝炎而闻名,慢性肝炎可导致包括肝硬化和肝细胞癌在内的严重并发症。全世界约有4亿人患有慢性肝炎,亚太地区是这一流行病的中心。本文旨在涵盖这些病毒的基本病毒学方面,并突出印度病毒性肝炎的现状。