Luan Xinglong, Zhang Yihe, Wu Jing, Jonkheijm Pascal, Li Guangtao, Jiang Lei, Huskens Jurriaan, An Qi
Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Science and Technology China University of Geosciences Beijing 100083 P. R. China.
School of Science China University of Geosciences Beijing 100083 P. R. China.
ChemistryOpen. 2016 Jun 30;5(4):331-8. doi: 10.1002/open.201600030. eCollection 2016 Aug.
The kinetics of supramolecular bindings are fundamentally important for molecular motions and spatial-temporal distributions in biological systems, but have rarely been employed in preparing artificial materials. This report proposes a bio-inspired concept to regulate dynamic gradients through the coupled supramolecular binding and diffusion process in receptor-embedded hydrogel matrices. A new type of hydrogel that uses cyclodextrin (CD) as both the gelling moiety and the receptors is prepared as the diffusion matrices. The diffusible guest, 4-aminoazobenzene, quickly and reversibly binds to matrices-bound CD during diffusion and generates steeper gradients than regular diffusion. Weakened bindings induced through UV irradiation extend the gradients. Combined with numerical simulation, these results indicate that the coupled binding-diffusion could be viewed as slowed diffusion, regulated jointly by the binding constant and the equilibrium receptor concentrations, and gradients within a bio-relevant extent of 4 mm are preserved up to 90 h. This report should inspire design strategies of biomedical or cell-culturing materials.
超分子结合动力学对于生物系统中的分子运动和时空分布至关重要，但很少用于制备人工材料。本报告提出了一种受生物启发的概念，通过受体嵌入水凝胶基质中的超分子结合和扩散耦合过程来调节动态梯度。制备了一种新型水凝胶，它使用环糊精（CD）作为凝胶部分和受体作为扩散基质。可扩散客体4-氨基偶氮苯在扩散过程中与基质结合的CD快速且可逆地结合，并产生比常规扩散更陡的梯度。通过紫外线照射诱导结合减弱可扩展梯度。结合数值模拟，这些结果表明结合-扩散耦合可被视为减缓的扩散，由结合常数和平衡受体浓度共同调节，并且在4毫米的生物相关范围内的梯度可保持长达90小时。本报告应能启发生物医学或细胞培养材料的设计策略。
