Department of Drug Science, University of Catania Catania, Italy.
Department Biomedical and Biotechnological Science, University of Catania Catania, Italy.
Front Cell Dev Biol. 2016 Aug 5;4:80. doi: 10.3389/fcell.2016.00080. eCollection 2016.
The growing data obtained from in vivo studies and clinical trials demonstrated the benefit of adult stem cells transplantation in diabetes; although an important limit is represented by their survival after the transplant. To this regard, recent reports suggest that genetic manipulation of stem cells prior to transplantation can lead to enhanced survival and better engraftment. The following review proposes to stimulate interest in the role of heme oxygenase-1 over-expression on transplantation of stem cells in diabetes, focusing on the clinical potential of heme oxygenase protein and activity to restore tissue damage and/or to improve the immunomodulatory properties of transplanted stem cells.
越来越多的来自于体内研究和临床试验的数据表明，成年干细胞移植对糖尿病是有益的；尽管一个重要的限制因素是移植后它们的存活率。关于这一点，最近的报告表明，在移植前对干细胞进行基因操作可以提高其存活率和更好的植入效果。以下综述旨在激发人们对血红素加氧酶-1 过表达在糖尿病干细胞移植中作用的兴趣，重点关注血红素氧合酶蛋白和活性在恢复组织损伤和/或改善移植干细胞的免疫调节特性方面的临床潜力。
