用于血管治疗的支架与基于细胞的组织工程

Scaffolds and Cell-Based Tissue Engineering for Blood Vessel Therapy.

作者信息

Hsia Kai, Yao Chao-Ling, Chen Wei-Min, Chen Jian-Haw, Lee Hsinyu, Lu Jen-Her

出版信息

Cells Tissues Organs. 2016;202(5-6):281-295. doi: 10.1159/000448169. Epub 2016 Aug 23.

Abstract

The increasing morbidity of cardiovascular diseases in modern society has made it crucial to develop a small-caliber blood vessel. In the absence of appropriate autologous vascular grafts, an alternative prosthesis must be constructed for cardiovascular disease patients. The aim of this article is to describe the advances in making cell-seeded cardiovascular prostheses. It also discusses the combinations of types of scaffolds and cells, especially autologous stem cells, which are suitable for application in tissue-engineered vessels with the favorable properties of mechanical strength, antithrombogenicity, biocompliance, anti-inflammation, fatigue resistance and long-term durability. This article highlights the advancements in cellular tissue-engineered vessels in recent years.

摘要

现代社会中心血管疾病发病率的不断上升使得开发小口径血管变得至关重要。在缺乏合适的自体血管移植物的情况下,必须为心血管疾病患者构建替代假体。本文的目的是描述制备细胞接种心血管假体的进展。它还讨论了支架和细胞类型的组合,特别是自体干细胞,这些组合适用于具有机械强度、抗血栓形成性、生物相容性、抗炎性、抗疲劳性和长期耐久性等良好特性的组织工程血管。本文重点介绍了近年来细胞组织工程血管的进展。

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