Owolabi Lukman Femi, Abdu Aliyu, Ibrahim Aliyu, Owolabi Desola Shakira, Nalado Aisha, Bappa Adamu, Taura Aminu Abdullahi
Department of Neurology, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.
Department of Nephrology, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.
Ann Afr Med. 2016 Jul-Sep;15(3):138-44. doi: 10.4103/1596-3519.188895.
The purpose of this comparative study was to evaluate cognitive function in end-stage renal disease (ESRD) patients in comparison with age, sex, and level of education-matched control.
This is a cross-sectional study involving 80 ESRD patients receiving maintenance hemodialysis treatment and recruited conservatively at the nephrology unit of our hospital. Eighty apparently healthy control, that were matched with the patients for age, sex and education, were also recruited. Following exclusion of depression and severe functional disability, a computer-assisted neuropsychological test, the FePsy, was used to assess memory, psychomotor speed, concentration and attention using simple auditory and visual reaction time tasks, recognition memory tests (RMTs), finger tapping task, and binary choice task (BCT) for both the ESRD patients and controls.
ESRD patients performed worse on simple auditory and visual reaction time tasks (P < 0.05), RMTs (P < 0.05), finger tapping task (P < 0.05), BCT, and computerized visual search task (P < 0.05).
Performance in memory, psychomotor tasks, concentration, and attention tasks were found to be reduced among patients with ESRD compared with age, sex and level of education-matched control.
本比较研究的目的是评估终末期肾病（ESRD）患者与年龄、性别和教育程度相匹配的对照组相比的认知功能。
这是一项横断面研究，纳入了80例在我院肾病科接受维持性血液透析治疗且经保守招募的ESRD患者。还招募了80名年龄、性别和教育程度与患者相匹配的明显健康的对照者。在排除抑郁症和严重功能残疾后，使用计算机辅助神经心理测试FePsy，通过简单听觉和视觉反应时间任务、识别记忆测试（RMT）、手指敲击任务以及二选一任务（BCT），对ESRD患者和对照者的记忆、精神运动速度、注意力和专注力进行评估。
ESRD患者在简单听觉和视觉反应时间任务（P < 0.05）、RMT（P < 0.05）、手指敲击任务（P < 0.05）、BCT以及计算机化视觉搜索任务（P < 0.05）中的表现较差。
与年龄、性别和教育程度相匹配的对照组相比，ESRD患者在记忆、精神运动任务、注意力和专注力任务方面的表现有所下降。
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