Schneiderbauer Roland, Martinache Stefanie, Engstner Monika, Enk Alexander H, Hadaschik Eva N
Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
Dermatol Ther. 2016 Nov;29(6):419-423. doi: 10.1111/dth.12403. Epub 2016 Aug 23.
Topical steroids are effective in treating bullous pemphigoid (BP). Autoantibodies against BP180 are related to disease activity, but correlation of these autoantibodies with response to topical steroid therapy has not yet been clearly evaluated. We investigate the usefulness of close and early monitoring of autoantibodies against BP180 and BP230 for assessment of response to therapy and early detection of therapeutic failure in BP patients treated topically. In eight BP patients under treatment with topical or systemic steroid therapy we retrospectively evaluated clinical course and autoantibodies against BP180 and BP230 as well as indirect immunofluorescence titres (IIF). Data were included at diagnosis, during hospitalization and follow-ups. Autoantibodies against BP180 parallel disease activity in all topically and as well as systemically treated patients. Autoantibodies against BP230 correlated in five out of eight patients. Autoantibodies directed against BP180 and, to a lesser degree, against BP230 correlate with the clinical course of topically treated BP patients. Monitoring autoantibodies against BP180 is a useful tool to evaluate the efficacy of topical therapy in BP.
外用糖皮质激素对治疗大疱性类天疱疮（BP）有效。抗BP180自身抗体与疾病活动相关，但这些自身抗体与外用糖皮质激素治疗反应的相关性尚未得到明确评估。我们研究了密切和早期监测抗BP180和BP230自身抗体对于评估外用治疗的BP患者的治疗反应和早期发现治疗失败的有用性。在8例接受外用或全身糖皮质激素治疗的BP患者中，我们回顾性评估了临床病程、抗BP180和BP230自身抗体以及间接免疫荧光滴度（IIF）。数据包括诊断时、住院期间和随访期间的情况。在所有接受外用和全身治疗的患者中，抗BP180自身抗体与疾病活动平行。8例患者中有5例抗BP230自身抗体存在相关性。针对BP180以及程度较轻的针对BP230的自身抗体与外用治疗的BP患者的临床病程相关。监测抗BP180自身抗体是评估BP外用治疗疗效的有用工具。
