在德黑兰两家医院对患有脑室内出血的早产儿脐带中的白细胞介素-6（IL-6）和促红细胞生成素（EPO）进行测量。

Measurement of interleukin-6 (IL-6) and erythropoietin (EPO) in umbilical cords of preterm infants with intraventricular hemorrhage in two hospitals in Tehran.

作者信息

Khosravi Nastaran, Badamchi Ali, Khalesi Nasrin, Tabatabaee Azardokht, Naghdalipour Mehri, Asgarian Ramin

机构信息

a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.

b Medical Microbiology, Pasteur Institute of Iran (IPI) , Tehran , Iran , and.

出版信息

J Matern Fetal Neonatal Med. 2017 Aug;30(15):1847-1850. doi: 10.1080/14767058.2016.1228055. Epub 2016 Sep 9.

DOI:10.1080/14767058.2016.1228055

PMID:27550623

Abstract

BACKGROUND

Intraventricular hemorrhage (IVH) is an important cause of death in premature infants. This study aimed to assess the association of the umbilical cord plasma levels of interleukin-6 (IL-6) and erythropoietin (EPO) with the occurrence and severity of IVH in premature infants.

METHODS

Fifty premature newborns of mothers with chorioamnionitis risk factor were selected via nonprobability sampling. The concentration of the cord plasma's IL-6 and erythropoietin were measured by enzyme-linked immunosorbent assay (ELISA) for 3 days. Finally, all samples underwent sonography for the diagnosis of IVH. Results analyzed statistically.

RESULTS

Among the samples, 68.98% of them were diagnosed with IVH grade 1. The most severe IVH cases were detected on the second day. The mean and standard deviation of IL-6 level was 74.71 ± 50.53 in the case group and 24.10 ± 46.10 in the control group. There was a correlation between IL-6 levels and IVH (p = 0.0005). The mean and standard deviation of EPO level was 18.38 ± 15.23 in the IVH group and 6.45 ± 13.48 in samples without IVH. A correlation was detected between EPO level and IVH (p = 0.005).

CONCLUSION

The concentration of IL-6 and EPO levels of the cord plasma was higher in the premature newborns with IVH.

摘要

背景

脑室内出血（IVH）是早产儿死亡的重要原因。本研究旨在评估脐带血血浆中白细胞介素-6（IL-6）和促红细胞生成素（EPO）水平与早产儿IVH发生及严重程度之间的关联。

方法

通过非概率抽样选取50例有绒毛膜羊膜炎危险因素母亲的早产新生儿。采用酶联免疫吸附测定（ELISA）法连续3天测量脐带血血浆中IL-6和促红细胞生成素的浓度。最后，所有样本均接受超声检查以诊断IVH。对结果进行统计学分析。

结果

在样本中，68.98%被诊断为1级IVH。最严重的IVH病例在第二天被检测到。病例组IL-6水平的均值和标准差分别为74.71±50.53，对照组为24.10±46.10。IL-6水平与IVH之间存在相关性（p = 0.0005）。IVH组EPO水平的均值和标准差分别为18.38±15.23，无IVH的样本为6.45±13.48。检测到EPO水平与IVH之间存在相关性（p = 0.005）。