药物性剥脱性皮炎：最新进展
Drug induced exfoliative dermatitis: state of the art.
作者信息
Yacoub Mona-Rita, Berti Alvise, Campochiaro Corrado, Tombetti Enrico, Ramirez Giuseppe Alvise, Nico Andrea, Di Leo Elisabetta, Fantini Paola, Sabbadini Maria Grazia, Nettis Eustachio, Colombo Giselda
机构信息
Department of Allergy and Clinical Immunology, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy ; Vita-Salute San Raffaele University, Milan, Italy.
Vita-Salute San Raffaele University, Milan, Italy.
出版信息
Clin Mol Allergy. 2016 Aug 22;14(1):9. doi: 10.1186/s12948-016-0045-0. eCollection 2016.
Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED.
药物性剥脱性皮炎（ED）是一组罕见且严重的药物超敏反应（DHR），累及皮肤，通常在接触药物后数天至数周内发生。多形红斑（EM）、史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是药物性ED的主要临床表现。总体而言，T细胞是这些免疫介导的药物反应的核心参与者。在此，我们对药物性ED患者的发生率、危险因素、发病机制、临床特征及治疗进行系统综述。
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