接种 COVID-19 疫苗后出现的一种极其罕见的黏膜皮肤不良反应：中毒性表皮坏死松解症。
An extremely rare mucocutaneous adverse reaction following COVID-19 vaccination: Toxic epidermal necrolysis.
机构信息
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Dermatol Ther. 2022 May;35(5):e15416. doi: 10.1111/dth.15416. Epub 2022 Mar 9.
Abstract
Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), is a type of delayed hypersensitivity reaction that requires urgent medical intervention. In the COVID-19 era, COVID-19 vaccines are currently being widely administered and mucocutaneous adverse reactions following vaccination have been reported; however, severe cutaneous adverse reactions associated with COVID-19 vaccines including SJS/TEN, are extremely rare. Herein, we describe a case of COVID-19 vaccination induced TEN which developed 1 day after receiving the first dose of Sinopharm COVID-19 vaccine with favorable clinical outcome.
摘要
史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）是一种迟发性超敏反应，需要紧急医疗干预。在 COVID-19 时代，目前正在广泛接种 COVID-19 疫苗，并报告了接种疫苗后的粘膜皮肤不良反应；然而，与 COVID-19 疫苗相关的严重皮肤不良反应，包括 SJS/TEN，极为罕见。在此，我们描述了一例 COVID-19 疫苗接种后 1 天发生的 TEN，该患者在接种首剂国药控股 COVID-19 疫苗后出现，临床结局良好。
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