Fegade Mayuresh V, Bhounsule Sushama A, Pereira Ian
Postgraduate Student, Postgraduate Student, Department of Pharmacology, Goa Medical College , India.
J Clin Diagn Res. 2012 Nov;6(9):1571-3. doi: 10.7860/JCDR/2012/4744.2566.
Toxic Epidermal Necrolysis (TEN), which is also known as Lyell's syndrome, is a widespread, life-threatening, mucocutaneous disease that is particularly observed secondary to drugtaking and less commonly secondary to infections and immunization. Carbamazepine is associated with benign pruritic rash in 10-15% of the patients, but the life threatening dermatological syndromes like exfoliative dermatitis, erythema multiforme, the Stevens-Johnson Syndrome (SJS) and TEN are rarely seen with the carbamazepine treatment. The 32 year old female suffering from chronic backache, who was prescribed carbamazepine along with an intravenous combination of vitamin B-complex and calcium, developed fever, cough and mucocutaneous manifestations of TEN after 15 days of the treatment. She was treated in the hospital with systemic steroids, intravenous immunoglobulins, antibiotics, intravenous fluids and supportive care. In spite of the above treatment, the patient could not survive for more than seven days.
中毒性表皮坏死松解症（TEN），也被称为莱尔综合征，是一种广泛传播、危及生命的黏膜皮肤疾病，尤其常见于用药后，较少继发于感染和免疫接种。卡马西平在10% - 15%的患者中会引发良性瘙痒性皮疹，但像剥脱性皮炎、多形红斑、史蒂文斯 - 约翰逊综合征（SJS）和中毒性表皮坏死松解症等危及生命的皮肤综合征在卡马西平治疗中很少见。一名32岁患有慢性背痛的女性，在接受卡马西平以及复合维生素B和钙的静脉联合治疗后，治疗15天后出现发热、咳嗽和中毒性表皮坏死松解症的黏膜皮肤表现。她在医院接受了全身类固醇、静脉注射免疫球蛋白、抗生素、静脉输液和支持性护理治疗。尽管进行了上述治疗，患者仍未能存活超过七天。
