Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei, 106, Taiwan.
Small. 2016 Oct;12(40):5524-5529. doi: 10.1002/smll.201601370. Epub 2016 Aug 23.
Silicon nanowire field-effect transistors modified with specific aptamers can directly detect the minute dopamine and neuropeptide Y released from cells. The binding of these molecules to the aptamers results in a conductance change of the transistor biosensor and illustrates the differential releasing mechanisms of these molecules stored in various vesicle pools.
经特定适体修饰的硅纳米线场效应晶体管可以直接检测从细胞中释放的微量多巴胺和神经肽 Y。这些分子与适体的结合导致晶体管生物传感器的电导率发生变化，说明了这些分子在各种囊泡池中储存的不同释放机制。
