Wang Jingfeng, Chen Duo, Huang Wanting, Yang Nianjun, Yuan Quan, Yang Yanbing
College of Chemistry and Molecular Sciences, Institute of Molecular Medicine Renmin Hospital of Wuhan University, School of Microelectronics, Wuhan University Wuhan China.
Department of Chemistry, Insititute of Materials Research Hasselt University Hasselt Belgium.
Exploration (Beijing). 2023 May 11;3(3):20210027. doi: 10.1002/EXP.20210027. eCollection 2023 Jun.
Nano-biosensors that are composed of recognition molecules and nanomaterials have been extensively utilized in disease diagnosis, health management, and environmental monitoring. As a type of nano-biosensors, molecular specificity field-effect transistor (FET) biosensors with signal amplification capability exhibit prominent advantages including fast response speed, ease of miniaturization, and integration, promising their high sensitivity for molecules detection and identification. With intrinsic characteristics of high stability and structural tunability, aptamer has become one of the most commonly applied biological recognition units in the FET sensing fields. This review summarizes the recent progress of FET biosensors based on aptamer functionalized nanomaterials in medical diagnosis and environmental monitoring. The structure, sensing principles, preparation methods, and functionalization strategies of aptamer modified FET biosensors were comprehensively summarized. The relationship between structure and sensing performance of FET biosensors was reviewed. Furthermore, the challenges and future perspectives of FET biosensors were also discussed, so as to provide support for the future development of efficient healthcare management and environmental monitoring devices.
由识别分子和纳米材料组成的纳米生物传感器已广泛应用于疾病诊断、健康管理和环境监测。作为一种纳米生物传感器，具有信号放大能力的分子特异性场效应晶体管（FET）生物传感器具有突出的优点，包括响应速度快、易于小型化和集成，有望实现对分子检测和识别的高灵敏度。适配体具有高稳定性和结构可调性的内在特性，已成为FET传感领域最常用的生物识别单元之一。本文综述了基于适配体功能化纳米材料的FET生物传感器在医学诊断和环境监测方面的最新进展。全面总结了适配体修饰的FET生物传感器的结构、传感原理、制备方法和功能化策略。综述了FET生物传感器的结构与传感性能之间的关系。此外，还讨论了FET生物传感器面临的挑战和未来展望，以便为高效医疗管理和环境监测设备的未来发展提供支持。
