Tian Yun Fan, Zhou Yi Peng, Zhong Chong Ke, Buren Batu, Xu Tian, Li Hong Mei, Zhang Ming Zhi, Wang Ai Li, Zhang Yong Hong
Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
Department of Epidemiology, Tongliao Center for Disease Prevention and Control, Tongliao 028005, Inner Mongolia, China.
Biomed Environ Sci. 2016 Jul;29(7):467-74. doi: 10.3967/bes2016.062.
We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
From June 2003 to July 2012, 2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation. All the participants were divided into four subgroups according to C-reactive protein (CRP) level and ApoB/ApoA-1 ratio. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the IS and CHD events in all the subgroups.
The HRs (95% CI) for IS and CHD were 1.33 (0.84-2.12), 1.14 (0.69-1.88), and 1.91 (1.17-3.11) in the 'low CRP level with high ApoB/ApoA-1', 'high CRP level with low ApoB/ApoA-1', and 'high CRP level with high ApoB/ApoA-1' subgroups, respectively, in comparison with the 'low CRP level with low ApoB/ApoA-1' subgroup. The risks of IS and CHD events was highest in the 'high CRP level with high ApoB/ApoA-1' subgroup, with statistical significance.
High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population. This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.
我们旨在研究高C反应蛋白（CRP）水平和载脂蛋白B与载脂蛋白A-1（ApoB/ApoA-1）比值对中国蒙古族人群缺血性卒中（IS）或冠心病（CHD）发病率的累积影响。
2003年6月至2012年7月，对2589名蒙古族参与者进行基线调查，并随访其IS和CHD事件。所有参与者根据CRP水平和ApoB/ApoA-1比值分为四个亚组。采用Cox比例风险模型估计所有亚组中IS和CHD事件的风险比（HRs）及95%置信区间（CIs）。
与“低CRP水平且低ApoB/ApoA-1”亚组相比，“低CRP水平且高ApoB/ApoA-1”、“高CRP水平且低ApoB/ApoA-1”和“高CRP水平且高ApoB/ApoA-1”亚组中IS和CHD的HRs（95%CI）分别为1.33（0.84-2.12）、1.14（0.69-1.88）和1.91（1.17-3.11）。“高CRP水平且高ApoB/ApoA-1”亚组中IS和CHD事件的风险最高，具有统计学意义。
高CRP水平且高ApoB/ApoA-1比值与蒙古族人群中IS和CHD的最高风险相关。本研究表明，CRP与ApoB/ApoA-1比值的联合可能改善对一般人群发生IS和CHD未来风险的评估。
