伊朗人群中18号染色体q11.2位点rs4331426多态性与肺结核之间无关联。

Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population.

作者信息

Naderi Mohammad, Hashemi Mohammad, Bahari Gholamreza

机构信息

Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.

Cellular and Molecular Research Center,Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran; epartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.

出版信息

Biomed Environ Sci. 2016 Jul;29(7):516-20. doi: 10.3967/bes2016.067.

DOI:10.3967/bes2016.067

PMID:27554121

Abstract

OBJECTIVE

The effect of rs4331426 polymorphism in the Chr18q11.2 locus on pulmonary tuberculosis (PTB) risk was evaluated.

METHODS

This case-control study included 208 PTB patients and 204 healthy subjects. Genotyping of the rs4331426 variant was conducted using polymerase chain reaction restriction fragment length polymorphism.

RESULTS

The frequencies of genotypes AA, AG, and GG polymorphisms were 83.1%, 15.9%, and 1.0% in the PTB group and 84.3%, 15.2%, and 0.5% in the control group, respectively. The frequency of the minor (G) allele was 8.9% in the PTB group and 8.1% in controls. Neither genotype nor allele frequencies of the rs4331426 variant showed statistically significant differences between PTB and controls. In addition, stratification by sex showed no significant association between the rs4331426 variant and PTB risk in males or females.

CONCLUSION

In conclusion, the results of this study do not support an association between the rs4331426 polymorphism and risk of PTB in an Iranian population.

摘要

目的

评估18号染色体q11.2位点的rs4331426多态性对肺结核（PTB）风险的影响。

方法

本病例对照研究纳入了208例PTB患者和204名健康受试者。采用聚合酶链反应-限制性片段长度多态性方法对rs4331426变异进行基因分型。

结果

PTB组中AA、AG和GG多态性基因型的频率分别为83.1%、15.9%和1.0%，对照组中分别为84.3%、15.2%和0.5%。PTB组中次要（G）等位基因的频率为8.9%，对照组为8.1%。rs4331426变异的基因型和等位基因频率在PTB组和对照组之间均无统计学显著差异。此外，按性别分层显示，rs4331426变异与男性或女性的PTB风险之间无显著关联。