用于心脏再生的直接心脏细胞重编程
Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
作者信息
Patel Vivekkumar, Mathison Megumi, Singh Vivek P, Yang Jianchang, Rosengart Todd K
机构信息
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA.
出版信息
Curr Treat Options Cardiovasc Med. 2016 Sep;18(9):58. doi: 10.1007/s11936-016-0480-8.
Abstract
Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.
摘要
将内源性心脏成纤维细胞直接重编程为诱导性心肌细胞，对于晚期心力衰竭患者而言是一种高度可行且前景广阔的治疗选择。最成功的心脏重编程策略可能是一种多模式方法，涉及心脏分化因子的最佳组合、成纤维细胞基因表达的抑制以及血管生成因子的诱导。
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