Psoter Walter J, Nelson Evelyn M, Psoter Kevin J, Dearing Bianca A, Katz Ralph V, Catalanotto Frank
Director of Dental Research, Department of Dental Medicine, NYU-Lutheran Medical Center, Brooklyn, NY, USA; and Associate Professor, University of Rochester, Eastman Institute for Oral Health, Rochester NY, USA.
Clinical Assistant Professor, Cariology and Comprehensive Care, New York University College of Dentistry, New York, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Oct;122(4):442-7. doi: 10.1016/j.oooo.2016.06.010. Epub 2016 Jun 29.
There is limited evidence that early deficits in growth might be reflected in tooth emergence in children infected with human immunodeficiency virus (HIV). The purpose of this study was to prospectively evaluate tooth emergence timing between children positive and negative for HIV in the exposed and unexposed groups, respectively.
A longitudinal study of children positive for HIV and HIV-negative household peers, aged 2 to 15 years was conducted between 1993 and 1996. Emergence status was determined for the maxillary and the mandibular permanent first molars and the central and lateral incisors. A multivariable, discrete time, proportional hazards model was fitted to the data. Median age of emergence for each of the six pairs of teeth was calculated using the parameter estimates from the regression model.
A total of 116 participants (62 HIV positive, 54 HIV negative) completed six examinations over the 36-month study period. Statistical differences in tooth emergence timing were observed for five of the six tooth pairs, with children positive for HIV being less likely to have emergence of the corresponding tooth compared with the children negative for HIV. Age differences for each tooth pair ranged from 0.7 to 1.5 years, with a median emergence age difference of 1.03 years.
Delayed tooth emergence of the permanent dentition was observed in children with HIV.
有有限的证据表明，感染人类免疫缺陷病毒（HIV）的儿童生长早期缺陷可能反映在牙齿萌出方面。本研究的目的是前瞻性评估暴露组和未暴露组中HIV阳性和阴性儿童的牙齿萌出时间。
1993年至1996年对2至15岁的HIV阳性儿童及其HIV阴性家庭同伴进行了一项纵向研究。确定上颌和下颌第一恒磨牙以及中切牙和侧切牙的萌出情况。对数据拟合多变量、离散时间、比例风险模型。使用回归模型的参数估计值计算六对牙齿中每一对的中位萌出年龄。
在36个月的研究期间，共有116名参与者（62名HIV阳性，54名HIV阴性）完成了六次检查。六对牙齿中有五对观察到牙齿萌出时间的统计学差异，与HIV阴性儿童相比，HIV阳性儿童相应牙齿萌出的可能性较小。每对牙齿的年龄差异在0.7至1.5岁之间，中位萌出年龄差异为1.03岁。
观察到HIV感染儿童恒牙萌出延迟。
