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术前联合股神经和坐骨神经阻滞可改善前交叉韧带重建术后的镇痛效果:一项随机对照临床试验。

Combined preoperative femoral and sciatic nerve blockade improves analgesia after anterior cruciate ligament reconstruction: a randomized controlled clinical trial.

作者信息

Harbell Monica W, Cohen Joshua M, Kolodzie Kerstin, Behrends Matthias, Braehler Matthias R, Kinjo Sakura, Feeley Brian T, Aleshi Pedram

机构信息

Department of Anesthesia and Perioperative Care, University of California, San Francisco.

Department of Anesthesia and Perioperative Care, University of California, San Francisco.

出版信息

J Clin Anesth. 2016 Sep;33:68-74. doi: 10.1016/j.jclinane.2016.02.021. Epub 2016 Apr 29.

Abstract

STUDY OBJECTIVE

To compare preoperative femoral (FNB) with combined femoral and sciatic nerve block (CFSNB) in patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction.

DESIGN

Prospective, randomized clinical trial.

SETTING

Ambulatory surgery center affiliated with an academic medical center.

PATIENTS

Sixty-eight American Society of Anesthesiology physical status I and II patients undergoing arthroscopic ACL reconstruction.

INTERVENTIONS

Subjects randomized to the CFSNB group received combined femoral and sciatic nerve blocks preoperatively, whereas patients randomized to the FNB group only received femoral nerve block preoperatively. Both groups then received a standardized general anesthetic with a propofol induction followed by sevoflurane or desflurane maintenance. Intraoperative pain was treated with fentanyl. Pain in the postanesthesia care unit (PACU) was treated with ketorolac and opiates. Patients with significant pain despite ketorolac and opiates could receive a rescue nerve block.

MEASUREMENTS

Our primary outcome variable was highest Numeric Rating Scale (NRS) pain score in PACU. NRS pain scores, opioid consumption, opioid adverse effects, and patient satisfaction were assessed perioperatively until postoperative day 3.

MAIN RESULTS

The highest PACU NRS pain score was significantly higher in the FNB group compared with the CFSNB group (7 [3-10] vs 5 [0-10], P=.002). The FNB group required significantly larger doses of opioids perioperatively (31.8 vs 19.8mg intravenous morphine equivalents, P<.001). PACU length of stay was significantly longer in the FNB group (128.2 vs 103.1minutes, P=.006). There was no significant difference in opioid consumption, pain scores, or patient satisfaction on postoperative days 1-3 between groups.

CONCLUSIONS

Preoperative CFSNB for arthroscopic ACL reconstruction improves analgesia, decreases opioid consumption perioperatively, and decreases PACU length of stay when compared with FNB alone.

摘要

研究目的

比较关节镜下前交叉韧带(ACL)重建患者术前股神经阻滞(FNB)与股神经联合坐骨神经阻滞(CFSNB)的效果。

设计

前瞻性随机临床试验。

地点

一所学术医疗中心附属的门诊手术中心。

患者

68例美国麻醉医师协会身体状况为I级和II级、接受关节镜下ACL重建的患者。

干预措施

随机分配至CFSNB组的受试者术前接受股神经联合坐骨神经阻滞,而随机分配至FNB组的患者术前仅接受股神经阻滞。两组随后均接受标准化全身麻醉,先以丙泊酚诱导,然后用七氟醚或地氟醚维持。术中疼痛用芬太尼治疗。麻醉后护理单元(PACU)的疼痛用酮咯酸和阿片类药物治疗。尽管使用了酮咯酸和阿片类药物仍有明显疼痛的患者可接受补救性神经阻滞。

测量指标

我们的主要结局变量是PACU中最高的数字评定量表(NRS)疼痛评分。在围手术期直至术后第3天评估NRS疼痛评分、阿片类药物消耗量、阿片类药物不良反应和患者满意度。

主要结果

与CFSNB组相比,FNB组PACU中最高NRS疼痛评分显著更高(7 [3 - 10] 对5 [0 - 10],P = 0.002)。FNB组围手术期需要显著更大剂量的阿片类药物(31.8对19.8mg静脉注射吗啡当量,P < 0.001)。FNB组PACU住院时间显著更长(128.2对103.1分钟,P = 0.006)。两组术后第1 - 3天的阿片类药物消耗量、疼痛评分或患者满意度无显著差异。

结论

与单独的FNB相比,关节镜下ACL重建术前进行CFSNB可改善镇痛效果,减少围手术期阿片类药物消耗量,并缩短PACU住院时间。

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