Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, United States of America.
Department of Anesthesia and Perioperative Medicine, Mayo Clinic, Phoenix, Arizona, United States of America.
PLoS One. 2021 Feb 18;16(2):e0246792. doi: 10.1371/journal.pone.0246792. eCollection 2021.
This randomized study compared the efficacy and safety of extraplexus and intraplexus injection of local anesthetic for interscalene brachial plexus block.
208 ASA I-II patients scheduled for elective shoulder arthroscopy under general anesthesia and ultrasound-guided interscalene brachial plexus block were randomly allocated to receive an injection of 25mL ropivacaine 0.5% either between C5-C6 nerve roots (intraplexus), or anterior and posterior to the brachial plexus into the plane between the perineural sheath and scalene muscles (extraplexus). The primary outcome was time to loss of shoulder abduction. Secondary outcomes included block duration, perioperative opioid consumption, pain scores, block performance time, number of needle passes, onset of sensory blockade, paresthesia, recovery room length of stay, patient satisfaction, incidence of Horner's syndrome, dyspnea, hoarseness, and post-operative nausea and vomiting.
Time to loss of shoulder abduction was faster in the intraplexus group (log-rank p-value<0.0005; median [interquartile range]: 4 min [2-6] vs. 6 min [4-10]; p-value <0.0005). Although the intraplexus group required fewer needle passes (2 vs. 3, p<0.0005), it resulted in more transient paresthesia (35.9% vs. 14.5%, p = 0.0004) with no difference in any other secondary outcome.
The intraplexus approach to the interscalene brachial plexus block results in a faster onset of motor block, as well as sensory block. Both intraplexus and extraplexus approaches to interscalene brachial plexus block provide effective analgesia. Given the increased incidence of paresthesia with an intraplexus approach, an extraplexus approach to interscalene brachial plexus block is likely a more appropriate choice.
本随机研究比较了外周丛和神经丛内注射局部麻醉药用于肌间沟臂丛神经阻滞的疗效和安全性。
208 例 ASA I-II 级择期全身麻醉下肩关节镜手术患者,在超声引导下进行肌间沟臂丛神经阻滞,随机分为两组,每组 25mL 0.5%罗哌卡因,分别注入 C5-C6 神经根之间(神经丛内)或臂丛神经前后方至神经外膜与斜角肌之间的平面(外周丛)。主要结局是肩外展丧失的时间。次要结局包括阻滞持续时间、围术期阿片类药物消耗、疼痛评分、阻滞起效时间、针数、感觉阻滞起效、感觉异常、恢复室停留时间、患者满意度、霍纳综合征发生率、呼吸困难、声音嘶哑和术后恶心呕吐。
神经丛内组肩外展丧失时间更快(对数秩检验,p 值<0.0005;中位数[四分位间距]:4 分钟[2-6]比 6 分钟[4-10];p 值<0.0005)。虽然神经丛内组需要的针数更少(2 比 3,p<0.0005),但感觉异常更短暂(35.9%比 14.5%,p=0.0004),其他次要结局无差异。
肌间沟臂丛神经阻滞的神经丛内入路可更快地产生运动阻滞和感觉阻滞。神经丛内和神经丛外入路均可提供有效的镇痛。鉴于神经丛内入路感觉异常发生率增加,神经丛外入路可能是肌间沟臂丛神经阻滞更合适的选择。