Oddi括约肌功能障碍的转化医学与临床研究视角
Translational and clinical perspectives on sphincter of Oddi dysfunction.
作者信息
Kyanam Kabir Baig Kondal Rao, Wilcox Charles Melbern
机构信息
Division of Gastroenterology and Hepatology, University of Alabama; Birmingham VA Medical Center, Birmingham, AL, USA.
Division of Gastroenterology and Hepatology, University of Alabama.
出版信息
Clin Exp Gastroenterol. 2016 Jul 28;9:191-5. doi: 10.2147/CEG.S84018. eCollection 2016.
Abstract
Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms thought to be responsible for symptomatology, review recent major studies, explore endoscopic and pharmacologic therapies and their efficacy, and to explore future research avenues.
摘要
Oddi括约肌功能障碍是一种复杂的病理生理实体，与引起腹痛、恶心和呕吐的显著发病率相关。本综述的目的是描述Oddi括约肌的解剖学和生理学，了解被认为是症状学原因的病理机制，回顾近期的主要研究，探讨内镜和药物治疗及其疗效，并探索未来的研究途径。
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