Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Busan 602-739, Republic of Korea.
Radiographics. 2009 Oct;29(6):1707-24. doi: 10.1148/rg.296095501.
The hepatocyte-specific contrast agent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) was developed to improve the detection and characterization of focal liver lesions at magnetic resonance (MR) imaging. Approximately 50% of the injected dose is taken up into the functional hepatocyte and is excreted via the biliary system. Because of this property, Gd-EOB-DTPA has the potential to be a biliary contrast agent. When combined with T2-weighted MR cholangiography, Gd-EOB-DTPA-enhanced MR imaging can allow morphologic and functional assessment of the biliary system. Gd-EOB-DTPA-enhanced MR cholangiography could be effective in evaluation of biliary anatomy, differentiation of biliary from extrabiliary lesions, diagnosis of cholecystitis, assessment of bile duct obstruction, detection of bile duct injury including leakage and stricture, evaluation of biliary-enteric anastomoses, postprocedure evaluation, differentiation of biloma from other pathologic conditions, and evaluation of sphincter of Oddi dysfunction. However, the clinical applications of this imaging technique have not yet been fully explored, and further investigations are needed to determine the utility of Gd-EOB-DTPA-enhanced MR cholangiography in a clinical setting.
肝脏特异性对比剂钆塞酸二钠（Gd-EOB-DTPA）的开发是为了提高磁共振成像（MR）对肝脏局灶性病变的检测和特征描述能力。大约 50%的注射剂量被功能性肝细胞摄取，并通过胆道系统排泄。由于这种特性，Gd-EOB-DTPA 有可能成为一种胆道造影剂。当与 T2 加权 MR 胆管成像结合使用时，Gd-EOB-DTPA 增强 MR 成像可以对胆道系统进行形态和功能评估。Gd-EOB-DTPA 增强 MR 胆管成像在评估胆道解剖结构、区分胆道和胆道外病变、诊断胆囊炎、评估胆管梗阻、检测胆管损伤包括漏出和狭窄、评估胆管-肠吻合口、术后评估、区分胆汁瘤与其他病理情况、评估Oddi 括约肌功能障碍方面可能有效。然而，该成像技术的临床应用尚未得到充分探索，需要进一步研究以确定 Gd-EOB-DTPA 增强 MR 胆管成像在临床环境中的应用价值。
