Department of Anesthesiology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):3-7. doi: 10.1016/j.bbalip.2016.08.010. Epub 2016 Aug 21.
Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid that is specific to mitochondria and although it is merely a minor component, accounting for 10-20% of the total phospholipid content, cardiolipin plays an important role in the molecular organization, and thus the function of the cristae. This review covers the formation of cardiolipin, a phospholipid dimer containing two phosphatidyl residues, and its assembly into mitochondrial membranes. While a large body of literature exists on this topic, the review focuses on papers that appeared in the past three years. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
在线粒体脂质中，心磷脂占据着独特的地位。它是唯一一种特异存在于线粒体的磷脂，虽然它仅占总磷脂含量的 10-20%，但在心磷脂在嵴的分子组织和功能中起着重要作用。本篇综述涵盖了心磷脂的形成，心磷脂是一种含有两个磷脂酰基的磷脂二聚体，以及它在 线粒体膜中的组装。虽然关于这个主题已经有大量的文献，但这篇综述重点关注了过去三年发表的论文。本文是由 Guenther Daum 编辑的题为“线粒体的脂质”特刊的一部分。
