Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.
Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Immunol Rev. 2016 Sep;273(1):156-79. doi: 10.1111/imr.12439.
Phagocytosis, the regulated uptake of large particles (>0.5 μm in diameter), is essential for tissue homeostasis and is also an early, critical component of the innate immune response. Phagocytosis can be conceptually divided into three stages: phagosome, formation, maturation, and resolution. Each of these involves multiple reactions that require exquisite spatial and temporal orchestration. The molecular events underlying these stages are being unraveled and the current state of knowledge is briefly summarized in this article.
吞噬作用，即对大于 0.5μm 直径的大颗粒的调控性摄取，对组织内稳态至关重要，也是先天免疫反应的早期关键组成部分。吞噬作用可以从概念上分为三个阶段：吞噬体形成、成熟和解决。每个阶段都涉及到多个需要精细时空协调的反应。这些阶段的分子事件正在被揭示，本文简要总结了当前的知识状态。
