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Metastasis as an evolutionary process.转移作为一个进化过程。
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The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition.在检查点抑制时代，癌症免疫疗法的免疫监测的地点、时间和方法。
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Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.联合癌症治疗与免疫检查点阻断：干扰素信号的汇聚。
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Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody.微针贴片辅助递送抗 PD-1 抗体增强癌症免疫治疗。
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PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.用于癌症治疗的PD-L1（B7-H1）和PD-1通路阻断：作用机制、反应生物标志物及联合应用
Sci Transl Med. 2016 Mar 2;8(328):328rv4. doi: 10.1126/scitranslmed.aad7118.
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Biomaterials for enhancing anti-cancer immunity.用于增强抗癌免疫力的生物材料。
Curr Opin Biotechnol. 2016 Aug;40:1-8. doi: 10.1016/j.copbio.2016.02.001. Epub 2016 Feb 18.
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Melanoma in 2015: Immune-checkpoint blockade - durable cancer control.2015年黑色素瘤：免疫检查点阻断——持久的癌症控制
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8
Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.中性粒细胞胞外诱捕网促进手术应激后肝转移的发生与进展。
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Biomaterials and emerging anticancer therapeutics: engineering the microenvironment.生物材料与新兴抗癌疗法：构建微环境
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Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.抗程序性死亡蛋白1（PD-1）和抗程序性死亡配体1（PD-L1）免疫检查点抗体的毒性。
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通过 CpG 和抗 PD-1 抗体的程序性递送来引发炎症的癌症免疫治疗。

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody.

机构信息

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

出版信息

Adv Mater. 2016 Oct;28(40):8912-8920. doi: 10.1002/adma.201506312. Epub 2016 Aug 25.

DOI:10.1002/adma.201506312
PMID:27558441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5283805/
Abstract

Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. The controlled release of anti-PD1 and CpG ODN by CpG DNA-based "nano-cocoons" can induce considerable immune response, which in turn significantly prolongs the survival time of mice.

摘要

基于 CpG 纳米小囊的 PD-1 抗体和 CpG 寡脱氧核苷酸（CpG ODN）的炎症触发型联合递药已被证明可以利用术后炎症反应预防癌症复发。通过 CpG 基“纳米小囊”的控释可以诱导相当大的免疫反应，从而显著延长小鼠的生存时间。