从一名阿尔茨海默病（AD）女性患者中建立早老素1（PSEN1）突变诱导多能干细胞（iPSC）系。 - Suppr

Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient.

作者信息

Nemes Csilla, Varga Eszter, Táncos Zsuzsanna, Bock István, Francz Barbara, Kobolák Julianna, Dinnyés András

机构信息

BioTalentum Ltd., Gödöllő, Hungary.

BioTalentum Ltd., Gödöllő, Hungary; Molecular Animal Biotechnology Laboratory, Szent István University, Gödöllő, Hungary.

出版信息

Stem Cell Res. 2016 Jul;17(1):69-71. doi: 10.1016/j.scr.2016.05.019. Epub 2016 May 24.

DOI:10.1016/j.scr.2016.05.019

PMID:27558604

Abstract

摘要

相似文献

Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient.从一名阿尔茨海默病（AD）女性患者中建立早老素1（PSEN1）突变诱导多能干细胞（iPSC）系。

Stem Cell Res. 2016 Jul;17(1):69-71. doi: 10.1016/j.scr.2016.05.019. Epub 2016 May 24.

Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation.从一名携带APP基因突变的阿尔茨海默病患者建立诱导多能干细胞系（ZZUi010-A）。

Stem Cell Res. 2017 Dec;25:213-216. doi: 10.1016/j.scr.2017.10.025. Epub 2017 Nov 3.

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.源自散发性阿尔茨海默病 iPSC 的神经元显示出 TAU 过度磷酸化增加、淀粉样蛋白水平升高和 GSK3β 激活。

Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z.

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1.从携带PSEN1基因A79V突变的阿尔茨海默病患者诱导多能干细胞系中生成基因校正的同基因对照细胞系。

Stem Cell Res. 2016 Sep;17(2):285-288. doi: 10.1016/j.scr.2016.08.002. Epub 2016 Aug 7.

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.早发性阿尔茨海默病的致病事件在携带PSEN1突变患者的诱导多能干细胞中得到证实。

Oncotarget. 2017 Jan 31;8(5):7900-7913. doi: 10.18632/oncotarget.13776.

Corrigendum to "Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD)" [Stem Cell Research 33(2018) 265-268].对“建立TUSMi007 - A，一株源自一名83岁中国汉族阿尔茨海默病（AD）患者的诱导多能干细胞（iPSC）系”[《干细胞研究》33(2018) 265 - 268]的勘误

Stem Cell Res. 2019 Apr;36:101412. doi: 10.1016/j.scr.2019.101412. Epub 2019 Feb 28.

Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease.从一名57岁散发性阿尔茨海默病患者建立诱导多能干细胞（iPSC）系。

Stem Cell Res. 2016 Jul;17(1):72-74. doi: 10.1016/j.scr.2016.05.020. Epub 2016 May 25.

Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD).从一名84岁迟发性阿尔茨海默病（LOAD）患者建立诱导多能干细胞（iPSC）系。

Stem Cell Res. 2016 Jul;17(1):75-77. doi: 10.1016/j.scr.2016.05.016. Epub 2016 May 24.

Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD).从一名63岁迟发性阿尔茨海默病（LOAD）患者建立诱导多能干细胞（iPSC）系。

Stem Cell Res. 2016 Jul;17(1):78-80. doi: 10.1016/j.scr.2016.05.014. Epub 2016 May 24.

Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD).从一名75岁迟发性阿尔茨海默病（LOAD）患者建立诱导多能干细胞（iPSC）系。

Stem Cell Res. 2016 Jul;17(1):81-83. doi: 10.1016/j.scr.2016.05.013. Epub 2016 May 24.

引用本文的文献

Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.家族性和散发性阿尔茨海默病 iPSC 来源的星形胶质细胞显示钙信号改变，并对错误折叠蛋白 Tau 产生不同反应。

Cells. 2022 Apr 22;11(9):1429. doi: 10.3390/cells11091429.

Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells.人诱导多能干细胞衍生神经元和小胶质细胞样细胞中P2X7受体的检测与功能评估

Front Mol Neurosci. 2022 Jan 12;14:793769. doi: 10.3389/fnmol.2021.793769. eCollection 2021.

Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer's Disease.阿尔茨海默病患者人神经元中单神经生长因子受体分子的活细胞成像。

Int J Mol Sci. 2021 Dec 9;22(24):13260. doi: 10.3390/ijms222413260.

Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells.脑源性神经营养因子可增加源自人诱导多能干细胞的神经祖细胞数量。

PeerJ. 2021 May 12;9:e11388. doi: 10.7717/peerj.11388. eCollection 2021.

Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.利用人诱导多能干细胞（hiPSCs）来研究载脂蛋白 E（APOE）如何导致阿尔茨海默病（AD）风险的机制。

Neurobiol Dis. 2020 May;138:104788. doi: 10.1016/j.nbd.2020.104788. Epub 2020 Feb 5.

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons.钙敏感受体激动剂 NPS 2143 可减少淀粉样蛋白分泌，并增加 PSEN1 突变型 iPSC 衍生神经元中 sAβPPα 的释放。

J Alzheimers Dis. 2019;72(3):885-899. doi: 10.3233/JAD-190602.

Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z.

3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish".阿尔茨海默病的3D培养模型：“盘中治愈”之路。

Mol Neurodegener. 2016 Dec 9;11(1):75. doi: 10.1186/s13024-016-0139-7.

Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and the Road Ahead.血液来源的诱导多能干细胞（iPSCs）：益处、挑战与未来之路。

J Alzheimers Dis Parkinsonism. 2016 Oct;6(5). doi: 10.4172/2161-0460.1000275. Epub 2016 Oct 25.

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Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient.

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