蛙皮素和胃泌素释放肽对清醒猫胃排空的双重作用。

Dual effect of bombesin and gastrin releasing peptide on gastric emptying in conscious cats.

作者信息

Chikh-Issa A R, Scarpignato C, Collinet M, Chayvialle J A, Vagne M

机构信息

INSERM U 45, Lyon, France.

出版信息

Peptides. 1989 Mar-Apr;10(2):281-7. doi: 10.1016/0196-9781(89)90031-4.

DOI:10.1016/0196-9781(89)90031-4

PMID:2755871

Abstract

The effect of bombesin (BBS) and gastrin releasing peptide (GRP) on gastric emptying was studied in conscious cats. This effect was measured simultaneously with antral motility. Acid and pepsin secretions as well as blood hormonal peptide release were additionally measured. A dual effect was observed. First, BBS and GRP slowed gastric emptying of liquids, while antral motility was decreased, then after 60 minutes of continuous intravenous infusion, antral motility returned to basal values and gastric emptying effect reversed. The mechanism of this peculiar action is independent of gastrin, pancreatic polypeptide, somatostatin and motilin release and most probably connected with a cholinergic stimulation induced by the peptides, the late predominance of which counterbalances the inhibitory effect of bombesin-like peptides on antral motility.

摘要

在清醒猫中研究了蛙皮素（BBS）和胃泌素释放肽（GRP）对胃排空的影响。该效应与胃窦运动同时进行测量。此外，还测量了胃酸和胃蛋白酶分泌以及血液中激素肽的释放。观察到了双重效应。首先，BBS和GRP减缓了液体的胃排空，同时胃窦运动降低，然后在连续静脉输注60分钟后，胃窦运动恢复到基础值，胃排空效应逆转。这种特殊作用的机制与胃泌素、胰多肽、生长抑素和胃动素的释放无关，很可能与这些肽诱导的胆碱能刺激有关，其后期优势抵消了蛙皮素样肽对胃窦运动的抑制作用。