犬血浆胃肠胰激素对蛙皮素和猪胃泌素释放肽（GRP）反应的定性比较

A qualitative comparison of canine plasma gastroenteropancreatic hormone response to bombesin and the porcine gastrin-releasing peptide (GRP).

作者信息

McDonald T J, Ghatei M A, Bloom S R, Track N S, Radziuk J, Dupre J, Mutt V

出版信息

Regul Pept. 1981 Sep;2(5):293-304. doi: 10.1016/0167-0115(81)90034-3.

Abstract

The effect on plasma gastroenteropancreatic hormone levels on infusing the porcine gastrin-releasing peptide and bombesin into dogs demonstrated no qualitative difference in the spectrum of activity of the two peptides. Sustained elevation in plasma immunoreactive gastrin, pancreatic polypeptide, enteroglucagon, gastric inhibitory polypeptide, pancreatic glucagon and transient elevations in plasma insulin were seen during infusions of both peptides. The similar spectrum of activities and the structural homology between the two peptides suggests that the porcine gastrin releasing peptide is the porcine counterpart of the amphibian peptide bombesin.

摘要

向犬体内输注猪胃泌素释放肽和蛙皮素对血浆胃肠胰激素水平的影响表明，这两种肽的活性谱没有质的差异。在输注这两种肽的过程中，均观察到血浆免疫反应性胃泌素、胰多肽、肠高血糖素、胃抑制多肽、胰高血糖素持续升高，血浆胰岛素短暂升高。这两种肽相似的活性谱和结构同源性表明，猪胃泌素释放肽是两栖类肽蛙皮素在猪体内的对应物。