Longhurst P A, Brotcke T P, Burrell C L, Belis J A
Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford.
Pharmacology. 1989;38(4):253-62. doi: 10.1159/000138544.
Contractile responses of androgen-sensitive smooth muscles such as the vas deferens and seminal vesicles are highly dependent upon the endocrine status of the animal. Although diabetes mellitus produces disturbances in reproductive function, including decreased serum androgen levels, the effects of diabetes on the contractile function of androgen-dependent urogenital smooth muscles have not been conclusively established. The present study compared the effects of streptozotocin-induced diabetes with those of castration on the contractile responses of rat vasa deferentia. Diabetes and castration produced significant decreases in serum testosterone levels, accompanied by significant decreases in vas deferens weights. Contractile responses of vasa deferentia from diabetic rats to carbachol, ATP, and phenylephrine were significantly increased, and responses to nerve stimulation were decreased. Similar results were obtained with vasa deferentia from castrated rats. Castration produced significant increases in contractile responses of vasa deferentia to carbachol and phenylephrine and decreased responses to nerve stimulation. The data suggest that both castration and diabetes produce a denervation-like supersensitivity which is specific for receptor-mediated processes.
雄激素敏感的平滑肌（如输精管和精囊）的收缩反应高度依赖于动物的内分泌状态。虽然糖尿病会导致生殖功能紊乱，包括血清雄激素水平降低，但糖尿病对雄激素依赖性泌尿生殖平滑肌收缩功能的影响尚未最终确定。本研究比较了链脲佐菌素诱导的糖尿病和去势对大鼠输精管收缩反应的影响。糖尿病和去势导致血清睾酮水平显著降低，同时输精管重量显著减轻。糖尿病大鼠输精管对卡巴胆碱、ATP和去氧肾上腺素的收缩反应显著增加，而对神经刺激的反应则降低。去势大鼠的输精管也得到了类似的结果。去势使输精管对卡巴胆碱和去氧肾上腺素的收缩反应显著增加，而对神经刺激的反应降低。数据表明，去势和糖尿病都会产生一种类似去神经的超敏反应，这种反应对受体介导的过程具有特异性。
