区域选择性碘催化烯丙基和烯胺构建多取代吡咯。
Regioselective Iodine-Catalyzed Construction of Polysubstituted Pyrroles from Allenes and Enamines.
机构信息
School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
出版信息
J Org Chem. 2016 Sep 16;81(18):8653-8. doi: 10.1021/acs.joc.6b01737. Epub 2016 Sep 2.
PMID:27559822
Abstract
A novel I2-catalyzed tandem Michael addition/oxidative annulation of allenes and enamines for the construction of polysubstituted pyrroles has been developed. This protocol represents an efficient and highly regioselective way to access functionalized pyrroles in moderate to excellent yields under mild conditions.
摘要
一种新型的 I2 催化的三组分迈克尔加成/氧化环化反应，用于构建多取代的吡咯化合物，已经被开发出来。该方法在温和条件下以中等至优秀的收率高效高区域选择性地构建了功能化的吡咯化合物。
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