MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University , Beijing 100084, China.
State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
J Org Chem. 2017 Nov 3;82(21):11391-11398. doi: 10.1021/acs.joc.7b01845.
A metal-free multicomponent domino reaction for the highly regioselective synthesis of tetrasubstituted NH-pyrroles from readily available alkylnitriles, arylalkynes, and MeOTf has been developed. A variety of NH-pyrroles were obtained in moderate to good yields under mild conditions. In addition, the reactions using diarylalkynes with electron-rich aryl groups were found to afford isoquinolines.
一种无金属的多组分多米诺反应，可从易得的烷基腈、芳基炔烃和 MeOTf 出发，高度区域选择性地合成四取代的 NH-吡咯。在温和条件下，以中等至良好的收率得到了各种 NH-吡咯。此外，发现使用富电子芳基的二芳基炔烃进行反应可得到异喹啉。
