Lancel M, Kerkhof G A
Research and Development Department, CIBA-GEIGY Ltd., Basel, Switzerland.
Physiol Behav. 1989 Feb;45(2):289-97. doi: 10.1016/0031-9384(89)90130-3.
This study was designed to examine the differences between sleep duration and EEG when sleep was restricted to the rest- or activity-phase for 5 successive days, achieved by repeated sleep deprivation in the dark (DSD) or light-period (LSD). In the DSD-experiment the percentages of the vigilance states were comparable to the level of the baseline light period. In LSD, the amounts of all sleep states increased substantially relative to baseline dark. The sleep episodes were lengthened in DSD and LSD. The duration of NREM-sleep and the sleep episodes remained longer in the light than in the dark, indicating circadian influences. In the first hours after sleep deprivation the delta activity during NREM-sleep was enhanced in LSD and to a lesser extent in DSD. This effect diminished over the consecutive days in both experiments. The EEG energy gained during sleep and its accumulation pattern on each day in DSD and LSD were strikingly similar, thereby reflecting a homeostatic process. After the sleep deprivation days, small changes were observed in the distribution of the vigilance states, the delta activity and EEG energy over the light- and dark-period.
本研究旨在通过在黑暗（DSD）或光照期（LSD）反复剥夺睡眠，连续5天将睡眠限制在休息期或活动期，来检验睡眠时间和脑电图之间的差异。在DSD实验中，警觉状态的百分比与基线光照期水平相当。在LSD实验中，所有睡眠状态的时长相对于基线黑暗期均大幅增加。DSD和LSD实验中的睡眠片段均延长。非快速眼动睡眠时长和睡眠片段在光照期比黑暗期更长，表明存在昼夜节律影响。在剥夺睡眠后的最初几个小时，LSD实验中非快速眼动睡眠期间的δ活动增强，DSD实验中增强程度较小。在两个实验中，这种效应在连续几天内逐渐减弱。DSD和LSD实验中睡眠期间获得的脑电图能量及其每天的积累模式惊人地相似，从而反映了一种稳态过程。在剥夺睡眠的日子之后，在光照期和黑暗期的警觉状态分布、δ活动和脑电图能量方面观察到了微小变化。
