Li Zhao, Guo Xiaofan, Liu Yamin, Sun Guozhe, Sun Yingxian, Guan Yufan, Zhu Guangshuo, Abraham Maria R
Department of Cardiology, the First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Pharmacy, Zhongda Hospital, Southeast University, Nanjing Jiangsu, China.
Am J Cardiol. 2016 Oct 15;118(8):1201-1206. doi: 10.1016/j.amjcard.2016.07.033. Epub 2016 Jul 29.
Until now, few studies have examined QT intervals in subjects who consume alcohol. We performed this study to evaluate the associations between alcohol consumption and the QTc interval based on a general population. A total of 11,269 adults were examined using a multistage cluster sampling method to select a representative sample of subjects aged ≥35 years. Participants were asked to provide information about their alcohol consumption, and all participants received electrocardiograms and echocardiograms. A prolonged QTc interval was defined according to the national guidelines, which specify thresholds of ≥460 ms in women and ≥450 ms in men. Patients were divided into 3 categories, based on the amount of alcohol they consumed: heavy drinkers (>15 g/day for women and >30 g/day for men), moderate drinkers (≤15 g/day for women and ≤30 g/day for men), and nondrinkers (0 g/day). The results showed that the heavy drinkers had longer QTc intervals than did the nondrinkers. Multivariate logistic regression analyses revealed that men who were heavy drinkers had approximately 1.4-fold higher odds of having a prolonged QTc interval (odds ratio 1.431, 95% confidence interval [CI] 1.033 to 1.982, p = 0.031) than nondrinkers; in women, heavy drinkers had ∼2.3-fold higher odds of having a prolonged QTc interval (odds ratio 2.344, 95% CI 1.202 to 4.571, p = 0.012) than nondrinkers. Neither men nor women who were moderate drinkers exhibited a significant increase in risk for prolonged QTc interval. In conclusion, heavy alcohol consumption was found to be a risk factor for a prolonged QTc interval.
到目前为止，很少有研究对饮酒者的QT间期进行过检测。我们开展这项研究，旨在基于普通人群评估饮酒与QTc间期之间的关联。采用多阶段整群抽样方法对11269名≥35岁的成年人进行检测，以选取具有代表性的样本。参与者被要求提供饮酒信息，所有参与者均接受了心电图和超声心动图检查。QTc间期延长根据国家指南定义，该指南规定女性阈值≥460毫秒，男性阈值≥450毫秒。根据饮酒量，患者被分为3类：酗酒者（女性>15克/天，男性>30克/天）、中度饮酒者（女性≤15克/天，男性≤30克/天）和不饮酒者（0克/天）。结果显示，酗酒者的QTc间期比不饮酒者更长。多因素逻辑回归分析显示，男性酗酒者QTc间期延长的几率比不饮酒者高约1.4倍（比值比1.431，95%置信区间[CI]为1.033至1.982，p = 0.031）；在女性中，酗酒者QTc间期延长的几率比不饮酒者高约2.3倍（比值比2.344，95%CI为1.202至4.571，p = 0.012）。中度饮酒的男性和女性QTc间期延长的风险均未显著增加。总之，大量饮酒被发现是QTc间期延长的一个风险因素。
