铁皮石斛多糖的抗氧化及保肝活性。
Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii.
机构信息
College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China.
出版信息
Carbohydr Polym. 2016 Nov 20;153:391-398. doi: 10.1016/j.carbpol.2016.07.067. Epub 2016 Jul 18.
The physicochemical properties (molecular weights and monosaccharide compositions), antioxidant and hepatoprotective activities of polysaccharides (ARPPs: ARPP30, ARPP60 and ARPP80) isolated from Anoectochilus roxburghii were investigated. ARPP80 exhibited relatively strong antioxidant activities in a concentration-dependent manner. In mice subjected to carbon tetrachloride-induced hepatotoxicity, ARPP80 pretreatment significantly (p<0.01) reduced the levels of aspartate and alanine amino transferases and malonyldialdehyde, prominently (p<0.01) restored the levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum or liver homogenate. These hepatoprotective effects were comparable to those of the standard drug silymarin at the same dose (200mg/kg). The study clearly demonstrated that ARPPs, especially ARPP80, might be suitable as functional foods or hepatoprotective drugs.
从铁皮石斛中分离得到的多糖（ARPP30、ARPP60 和 ARPP80）的理化性质（分子量和单糖组成）、抗氧化和保肝活性进行了研究。ARPP80 表现出相对较强的抗氧化活性，呈浓度依赖性。在四氯化碳诱导的小鼠肝毒性模型中，ARPP80 预处理可显著（p<0.01）降低天冬氨酸氨基转移酶和丙氨酸氨基转移酶及丙二醛的水平，明显（p<0.01）恢复血清或肝匀浆中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和还原型谷胱甘肽的水平。这些保肝作用与相同剂量（200mg/kg）的标准药物水飞蓟素相当。该研究清楚地表明，ARPPs，特别是 ARPP80，可能适合作为功能性食品或保肝药物。
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