Agrafiotis A C, Prieto M, Verhaeghe J-L, Siat J, Grosdidier G, Rios M
Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
Rev Pneumol Clin. 2016 Oct;72(5):293-295. doi: 10.1016/j.pneumo.2016.05.005. Epub 2016 Aug 22.
Soft tissue sarcomas are rare malignant tumors with a great variety of histological types and different response to multimodality treatment. Pazopanib has been recently introduced for the treatment of non-adipocytic metastatic soft tissue sarcomas which are resistant to conventional chemotherapy. Spontaneous pneumothorax is a rare but well recognized complication of this molecule and its treatment is quite challenging. The case reported herein describes the surgical management of a simultaneous bilateral spontaneous pneumothorax in a patient with pulmonary metastases treated with pazopanib. It underlines the fact that the main objective should be the maintenance of the treatment in patients who benefit from it. Close oncologic and surgical collaboration is crucial in order to deal with adverse effects due to the anti-angiogenic action of pazopanib.
软组织肉瘤是罕见的恶性肿瘤，具有多种组织学类型，对多模式治疗的反应也各不相同。帕唑帕尼最近已被用于治疗对传统化疗耐药的非脂肪细胞性转移性软组织肉瘤。自发性气胸是这种药物一种罕见但已得到充分认识的并发症，其治疗颇具挑战性。本文报道的病例描述了一名接受帕唑帕尼治疗的肺转移患者同时发生双侧自发性气胸的手术处理。它强调了一个事实，即在受益患者中，主要目标应是维持治疗。紧密的肿瘤学和外科协作对于应对帕唑帕尼抗血管生成作用导致的不良反应至关重要。
