Desai Mira K, Panchal Jigar R, Shah Samdih, Iyer Geetha
Department of Pharmacology, B. J. Medical College, Ahmedabad, Gujarat, India.
Department of Epidemiology Johns Hopkines Bloomberg School of Public Health, Baltimore, Maryland, USA.
Int J Appl Basic Med Res. 2016 Jul-Sep;6(3):205-10. doi: 10.4103/2229-516X.186967.
To find out the impact of teaching clinical pharmacology and rational therapeutics (CPT) to medical undergraduates (UGs) and interns.
This cross-sectional, prospective study was conducted on three UGs batches and interns using two pretested validated structured questionnaires, modified from the work of Tobaiqy et al. The study was approved by the Institutional Ethics Committee. ANOVA and Chi-square test were used for statistical analysis. The value of P < 0.05 was considered statistically significant.
A total of 379 UGs and 96 interns participated in this study. Mean knowledge score of interns was significantly reduced as compared to UGs (P < 0.0001). A significant increase in confidence for unsupervised prescribing of nonsteroidal anti-inflammatory drugs (99%), oral rehydration salt, iron salts was perceived among interns as compared to UGs (P < 0.05). However, 63.5% confessed problems in selection of drugs, drug-drug interactions, prescribing in special patient population. Although they were confident prescribing fixed dose combination for adult patients (89.5%), majority were hesitant to prescribe opioids (77%), steroids (76%), vaccines (75%), and antihypertensives (62%).
The theoretical CPT teaching transfers knowledge to UGs; however, it is not retained in internship and does not adequately prepare interns to prescribe safe and rational drugs.
了解向医学本科生和实习生讲授临床药理学与合理治疗学（CPT）的影响。
本横断面前瞻性研究对三个本科班学生和实习生进行，使用了两份经预测试验证的结构化问卷，该问卷由托巴基等人的作品修改而来。该研究获得机构伦理委员会批准。采用方差分析和卡方检验进行统计分析。P值<0.05被认为具有统计学意义。
共有379名本科生和96名实习生参与本研究。与本科生相比，实习生的平均知识得分显著降低（P<0.0001）。与本科生相比，实习生在非甾体抗炎药、口服补液盐、铁盐的无监督处方方面的信心显著增强（99%）（P<0.05）。然而，63.5%的人承认在药物选择、药物相互作用、特殊患者群体处方方面存在问题。尽管他们对为成年患者开具固定剂量复方制剂有信心（89.5%），但大多数人在开具阿片类药物（77%）、类固醇（76%）、疫苗（75%）和抗高血压药物（62%）时犹豫不决。
CPT理论教学将知识传授给了本科生；然而，这些知识在实习期间并未保留，也未使实习生充分具备开具安全合理药物的能力。
