尿毒症中的组织钙

Tissue calcium in uraemia.

作者信息

Krog M, Ejerblad S, Johansson H, Pettersson L

机构信息

Department of Surgery, University Hospital, Uppsala, Sweden.

出版信息

Scand J Urol Nephrol. 1989;23(2):141-4. doi: 10.3109/00365598909180829.

DOI:10.3109/00365598909180829

PMID:2756360

Abstract

The content of calcium in the thoracic aorta, the heart and the kidney was determined in rats with moderate renal failure treated with 1.25-dihydroxycholecalciferol (1.25-DHCC) 100 ng/kg/day and Verapamil 20 mg/kg/day. In the aorta the content of calcium was significantly increased in uraemic rats and this increase was significantly augmented after administration of 1.25-DHCC. In the kidney no increase in calcium was seen in rats with uraemia, but treatment with 1.25-DHCC increased the calcium content significantly. This increase was not correlated to the serum calcium x phosphate product, which was almost normal. In the heart no changes in the content of calcium were observed. Verapamil did not influence the effect of 1.25-DHCC. It is concluded that administration of 1.25-DHCC per se may increase the content of calcium in the aorta and kidney in rats with moderate uraemia and possibly in this way sensitize the tissue to the development of tissue calcification.

摘要

测定了用1,25 - 二羟胆钙化醇（1,25 - DHCC）100 ng/kg/天和维拉帕米20 mg/kg/天治疗的中度肾衰竭大鼠胸主动脉、心脏和肾脏中的钙含量。在主动脉中，尿毒症大鼠的钙含量显著增加，给予1,25 - DHCC后这种增加显著增强。在肾脏中，尿毒症大鼠未观察到钙增加，但用1,25 - DHCC治疗显著增加了钙含量。这种增加与几乎正常的血清钙×磷乘积无关。在心脏中，未观察到钙含量的变化。维拉帕米不影响1,25 - DHCC的作用。得出的结论是，给予1,25 - DHCC本身可能会增加中度尿毒症大鼠主动脉和肾脏中的钙含量，并可能以此方式使组织对组织钙化的发展敏感。