维生素D治疗对尿毒症大鼠胸主动脉中ATP水平降低及能荷的影响。
The effect of vitamin D treatment on decreased levels of ATP and energy charge in the thoracic aorta of uraemic rats.
作者信息
Krog M, Ejerblad S, Johansson H, Ronquist G
机构信息
Department of Clinical Research II, University Hospital, Uppsala, Sweden.
出版信息
Br J Exp Pathol. 1989 Apr;70(2):193-8.
The contents of ATP, ADP, AMP and calcium in the thoracic aorta were determined in rats with moderate uraemia, and in rats with the same degree of uraemia following treatment with 1,25-dihydroxycholecalciferol (1,25-DHCC). The contents of ATP, ADP and total nucleotides were decreased in the thoracic aorta in the uraemic rats but not in uraemic rats following 1,25-DHCC treatment. The content of calcium in the aorta increased substantially in uraemic rats given 1,25-DHCC. The results indicate that the development of arterial calcifications in uraemic rats following vitamin D treatment is dissociated from an impaired energy metabolism, since vitamin D may simultaneously restore impaired energy metabolism and accumulate calcium in the aortic wall.
测定中度尿毒症大鼠以及经1,25 - 二羟胆钙化醇（1,25 - DHCC）治疗的同等程度尿毒症大鼠胸主动脉中ATP、ADP、AMP和钙的含量。尿毒症大鼠胸主动脉中ATP、ADP和总核苷酸含量降低，但经1,25 - DHCC治疗的尿毒症大鼠未出现这种情况。给予1,25 - DHCC的尿毒症大鼠主动脉中的钙含量大幅增加。结果表明，维生素D治疗后尿毒症大鼠动脉钙化的发展与能量代谢受损无关，因为维生素D可能同时恢复受损的能量代谢并使钙在主动脉壁中蓄积。
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