Neoplasma. 2016;63(6):836-845. doi: 10.4149/neo_2016_602.
Cancer cells often rely on glycolytic metabolism in order to fulfill high demands of ATP and macromolecules for the sustained growth and proliferation. However, glycolysis is not necessarily the main source of energy for all cancer cells. Some of them rather depend on glutamine or lactate that favor the utilization of oxidative metabolic pathway. Different employment rate of metabolism creates variable products that participate in the formation of environmental milieu, which in turn triggers broad spectrum of cellular signaling pathways leading to migration, invasion, or proliferation. In this review we discuss different metabolic pathways promoted in tumor cells and describe the possibilities of their targeting as therapeutic strategies.
癌细胞通常依赖糖酵解代谢来满足 ATP 和大分子的高需求，以维持持续的生长和增殖。然而，糖酵解不一定是所有癌细胞的主要能量来源。其中一些癌细胞更依赖于谷氨酰胺或乳酸，这有利于氧化代谢途径的利用。不同的代谢利用率产生不同的产物，参与环境形成，进而触发广泛的细胞信号通路，导致迁移、侵袭或增殖。在这篇综述中，我们讨论了肿瘤细胞中促进的不同代谢途径，并描述了将其作为治疗策略的靶向可能性。
