Yoon Soo Jeong, Yoon Dae Young, Cho Young Kwon, Baek Sora, Lim Kyoung Ja, Seo Young Lan, Yun Eun Joo
Department of Radiology, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Acta Radiol. 2017 Jun;58(6):685-691. doi: 10.1177/0284185116665423. Epub 2016 Aug 26.
Background Animal research has played an important role in the field of radiology. Purpose To evaluate the characteristics and quality of published radiological animal research. Material and Methods A PubMed search was performed for radiological animal research articles (defined as studies using animal models with a radiologist as the first author) published in 1994, 2004, and 2014. The following information was extracted from each article: journal name, radiological subspecialty, imaging technique, animal species, number of animals used, number of authors, declared funding, country of origin, methodological quality, and ethical quality. Methodological and ethical quality of studies were assessed with seven-item (sample size calculation, animal age, animal sex, animal weight, inclusion and exclusion criteria, randomization, and blinded outcome assessment) and four-item (ethical review committee approval, anesthesia, pain control, and euthanasia) scales, respectively. Results The numbers of radiological animal studies markedly increased, from 91 in 1994 to 163 in 2004 and to 305 in 2014. One hundred and sixty-two (29.0%) articles focused on the neuroradiology/head and neck subspecialty, 233 (41.7%) used magnetic resonance imaging (MRI), 190 (34.0%) used mice, 254 (45.4%) used 10-30 animals, 297 (53.1%) had 4-7 authors, 392 (70.1%) were funded, and 222 (39.7%) were from the USA. Six of 7 methodological and 3/4 ethical quality items significantly improved over time. Conclusion The quantity and quality of radiological animal research has increased over the last two decades; however, methodological and ethical quality remains suboptimal.
背景 动物研究在放射学领域发挥了重要作用。目的 评估已发表的放射学动物研究的特征和质量。材料与方法 对1994年、2004年和2014年发表的放射学动物研究文章（定义为以放射科医生为第一作者使用动物模型的研究）进行PubMed检索。从每篇文章中提取以下信息：期刊名称、放射学亚专业、成像技术、动物种类、所用动物数量、作者数量、申报的资金、原产国、方法学质量和伦理质量。分别用七项量表（样本量计算、动物年龄、动物性别、动物体重、纳入和排除标准、随机化和盲法结局评估）和四项量表（伦理审查委员会批准、麻醉、疼痛控制和安乐死）评估研究的方法学和伦理质量。结果 放射学动物研究的数量显著增加，从1994年的91项增加到2004年的163项，再到2014年的305项。162篇（29.0%）文章聚焦于神经放射学/头颈亚专业，233篇（41.7%）使用磁共振成像（MRI），190篇（34.0%）使用小鼠，254篇（45.4%）使用10 - 30只动物，297篇（53.1%）有4 - 7名作者，392篇（70.1%）获得资助，222篇（39.7%）来自美国。随着时间的推移，7项方法学质量项目中的6项和4项伦理质量项目中的3项有显著改善。结论 在过去二十年中，放射学动物研究的数量和质量有所增加；然而，方法学和伦理质量仍未达到最佳状态。
